BACKGROUND: Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin
synthesis. TPH2 is a recently discovered isoform that is expressed predominantly in …

Tryptophan hydroxylase isoform 2 (TPH2) is a ratelimiting enzyme in the biosynthesis of
serotonin (5HT) and is predominantly localized in the brain. Previous studies have …

BACKGROUND: The tryptophan hydroxylase 1 (TPH1) gene is reported to be associated
with suicidal behavior. This has not been confirmed by prospective studies of suicide and …

Bipolar disorder (BD) is a severe psychiatric illness characterized by the occurrence of
elevated mood alternating with depressive episodes, having a estimated lifetime prevalence …

Background Genes encoding proteins involved in serotonergic metabolism are major
candidates in association studies of mood disorders and suicidal behavior. This association …

SEROTONERGIC dysfunction is implicated in mood disorders and suicidal behaviors.
Genetic variants of tryptophan hydroxylase (TPH), a rate-limiting enzyme in the biosynthesis …

BACKGROUND: Several studies have assessed the association between genetic
polymorphisms of tryptophan hydroxylase (TPH1) and risk of mood disorders and alcohol …

Background: Abnormalities in functioning of the central serotonergic system have been
implicated in the pathogenesis of depressive illness and suicidal behavior. Tryptophan …

BACKGROUND: Bipolar affective disorder (BPAD) is a common mental illness that is
strongly associated with suicide. Suicidal behavior is thought to result from an interaction of …

Objective: The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme
in the biosynthesis of serotonin, has many biological functions and plays an important role …