Serotonin is implicated in stress-related psychopathologies. Two isoforms of the rate-limiting
enzyme of serotonin biosynthesis, tryptophan hydroxylase, TPH1 and TPH2, are known. We …

BACKGROUND: Regulation of raphe serotonergic cells is fundamental to the prevailing
hypothesis of major depression pathophysiology. Tryptophan hydroxylase (TPH) is the rate …

Expression of TPH2, the rate-limiting enzyme for brain serotonin synthesis, is elevated in the
dorsal raphe nucleus (DR) of depressed suicide victims. One hypothesis is that this increase …

Repeated stress triggers a wide range of adaptive changes in the central nervous system
including the elevation of serotonin (5-HT) metabolism and an increased susceptibility to …

Alterations in brain serotonin levels are implicated in major depression and are regulated by
tryptophan hydroxylase2 (TPH2). To study its regulation, we measured TPH2 RNA by …

BACKGROUND: Recently a novel tryptophan hydroxylase isoform (TPH2) was identified
and shown to be highly expressed in the central nervous system (CNS). Hormonal effects on …

Serotonin is synthetized through the action of tryptophan hydroxylase (TPH) enzymes. While
the TPH2 isoform is responsible for the production of serotonin in the brain, TPH1 is …

Considerable attention has focused on regulation of central tryptophan hydroxylase (TPH)
activity and protein expression. At the time of these earlier studies, it was thought that there …

Depression and anxiety are among the leading causes of societal burden. Abnormalities in
5-hydroxytryptamine (5-HT; serotonin) neurotransmission are known to be associated with …

Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin (5-
hydroxytryptamine; 5-HT). Two isoforms of tryptophan hydroxylase, derived from different …