During progression of an in situ to an invasive cancer, epithelial cells lose expression of
proteins that promote cell–cell contact, and acquire mesenchymal markers, which promote …

Activation of the transcription factor NF-? B occurs in many human tumors, and studies have
shown that NF-κB can promote cell proliferation and oncogenesis, possibly by protecting …

NF-κB transcription factors are critical regulators of innate and adaptive immunity and major
mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant …

The transcription factor NF-κB is activated in a range of human cancers and is thought to
promote tumorigenesis, mainly due to its ability to protect transformed cells from apoptosis …

The role of the transcription factor NF-κB in shaping the cancer microenvironment is
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …

Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …

Recently it was discovered that a transient activation of transcription factor NF-κB can give
cells properties essential for invasiveness and cancer initiating potential. In contrast, most …

We reported previously that transcription factor nuclear factor (NF)-κB is constitutively
activated in human and murine squamous cell carcinomas (SCCs). The role of NF-κB in the …

NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …

A connection between inflammation and carcinogenesis has long been known, but the
precise mechanisms are just beginning to be understood. NF-κB proteins, transcription …