Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders
MA Enoch, KV White, J Waheed… - Depression and …, 2008 - Wiley Online Library
Anxiety disorders are often comorbid with major depression (MD) and alcohol use disorders
(AUD). Two common functional polymorphisms in catechol‐O‐methyltransferase (COMT …
(AUD). Two common functional polymorphisms in catechol‐O‐methyltransferase (COMT …
Shared genetic etiology between anxiety disorders and psychiatric and related intermediate phenotypes
K Ohi, T Otowa, M Shimada, T Sasaki… - Psychological …, 2020 - cambridge.org
BackgroundPsychiatric disorders and related intermediate phenotypes are highly heritable
and have a complex, overlapping polygenic architecture. A large-scale genome-wide …
and have a complex, overlapping polygenic architecture. A large-scale genome-wide …
Psychophysiological markers of anxiety disorders and anxiety symptoms
In anxiety research, relative few psychophysiological studies have been conducted. In this
chapter, we presented previous studies that used different psychophsiological markers that …
chapter, we presented previous studies that used different psychophsiological markers that …
Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism
MA Enoch, K Xu, E Ferro, CR Harris… - Psychiatric …, 2003 - journals.lww.com
Objective Women are more prone to anxiety than men. The catechol-O-methyltransferase
functional polymorphism, Val158Met, is likely to be implicated in anxiety vulnerability. We …
functional polymorphism, Val158Met, is likely to be implicated in anxiety vulnerability. We …
Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes
JM Hettema, SS An, J Bukszar, EJCG Van den Oord… - Biological …, 2008 - Elsevier
BACKGROUND: Catechol-O-methyl transferase (COMT) has been investigated for its
possible role in a wide range of psychiatric phenotypes. In particular, several studies support …
possible role in a wide range of psychiatric phenotypes. In particular, several studies support …
Genetics of anxiety: would the genome recognize the DSM?
JW Smoller, E Gardner‐Schuster… - Depression and …, 2008 - Wiley Online Library
The nosology of anxiety disorders has undergone substantial evolution over the past several
decades. The modern classification of these disorders dates to the publication of Diagnostic …
decades. The modern classification of these disorders dates to the publication of Diagnostic …
Genetic factors in anxiety disorders
K Domschke, E Maron - Anxiety disorders, 2013 - karger.com
Presently available clinical genetic studies point to a considerable heritability of anxiety
disorders (30-67%), with multiple vulnerability genes such as 5-HT 1A, 5-HTT, MAO-A …
disorders (30-67%), with multiple vulnerability genes such as 5-HT 1A, 5-HTT, MAO-A …
Heritability of major depressive and comorbid anxiety disorders in multi‐generational families at high risk for depression
G Guffanti, MJ Gameroff, V Warner… - American Journal of …, 2016 - Wiley Online Library
Family studies have shown that MDD is highly transmittable but have not studied its
heritability. Twin studies show heritability of about 40% and do not include anxiety disorders …
heritability. Twin studies show heritability of about 40% and do not include anxiety disorders …
Imaging genetics of anxiety disorders
K Domschke, U Dannlowski - Neuroimage, 2010 - Elsevier
Anxiety disorders are frequent and burdensome psychiatric diseases. Despite their
moderate to strong heritabilities, the search for candidate genes has been limited by …
moderate to strong heritabilities, the search for candidate genes has been limited by …
Reproducible genetic risk loci for anxiety: results from∼ 200,000 participants in the Million Veteran Program
Objective: Anxiety disorders are common and often disabling. The goal of this study was to
examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also …
examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also …