Anxiety disorders are often comorbid with major depression (MD) and alcohol use disorders
(AUD). Two common functional polymorphisms in catechol‐O‐methyltransferase (COMT …

BackgroundPsychiatric disorders and related intermediate phenotypes are highly heritable
and have a complex, overlapping polygenic architecture. A large-scale genome-wide …

In anxiety research, relative few psychophysiological studies have been conducted. In this
chapter, we presented previous studies that used different psychophsiological markers that …

Objective Women are more prone to anxiety than men. The catechol-O-methyltransferase
functional polymorphism, Val158Met, is likely to be implicated in anxiety vulnerability. We …

BACKGROUND: Catechol-O-methyl transferase (COMT) has been investigated for its
possible role in a wide range of psychiatric phenotypes. In particular, several studies support …

The nosology of anxiety disorders has undergone substantial evolution over the past several
decades. The modern classification of these disorders dates to the publication of Diagnostic …

Presently available clinical genetic studies point to a considerable heritability of anxiety
disorders (30-67%), with multiple vulnerability genes such as 5-HT 1A, 5-HTT, MAO-A …

Family studies have shown that MDD is highly transmittable but have not studied its
heritability. Twin studies show heritability of about 40% and do not include anxiety disorders …

Anxiety disorders are frequent and burdensome psychiatric diseases. Despite their
moderate to strong heritabilities, the search for candidate genes has been limited by …

Objective: Anxiety disorders are common and often disabling. The goal of this study was to
examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also …