Drosophila is a well-established model to study the molecular basis of neurodegenerative
diseases. We carried out a misexpression screen to identify genes involved in …

Age-dependent neurodegeneration is a pathological condition found in many metazoans.
Despite the biological and medical significance of this condition, the cellular and molecular …

Common neurodegenerative proteinopathies, such as Alzheimer's disease (AD) and
Parkinson's disease (PD), are characterized by the misfolding and aggregation of toxic …

In our ageing population, neurodegenerative disorders carry an enormous personal,
societal and economic burden. Although neurodegenerative diseases are often thought of …

Neurodegenerative diseases are one of the main causes of mental and physical disabilities.
Neurodegeneration has been estimated to begin many years before the first clinical …

Nervous system regulates homeostasis and adaptation to environmental changes of a
whole organism, thus deregulation of nervous processes accelerates aging (Alcedo et al …

Neurodegeneration is characterized by progressive loss of neurons. Genetic and
environmental factors both contribute to demise of neurons, leading to diverse devastating …

Neurodegenerative diseases are a complex set of disorders that are known to be caused by
environmental as well as genetic factors. In the recent past, mutations in a large number of …

The fruitfly Drosophila melanogaster has enabled significant advances in
neurodegenerative disease research, notably in the identification of genes that are required …

The ability of Drosophila genetics to reveal new insights into human neurodegenerative
disease is highlighted not only by mutants in flies that show neuronal cell loss, but also by …