[HTML][HTML] A Functional Misexpression Screen Uncovers a Role for Enabled in Progressive Neurodegeneration
C Rezaval, J Berni, EA Gorostiza, S Werbajh… - PLoS …, 2008 - journals.plos.org
Drosophila is a well-established model to study the molecular basis of neurodegenerative
diseases. We carried out a misexpression screen to identify genes involved in …
diseases. We carried out a misexpression screen to identify genes involved in …
Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila
MJ Palladino, TJ Hadley, B Ganetzky - Genetics, 2002 - academic.oup.com
Age-dependent neurodegeneration is a pathological condition found in many metazoans.
Despite the biological and medical significance of this condition, the cellular and molecular …
Despite the biological and medical significance of this condition, the cellular and molecular …
[HTML][HTML] Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease
Common neurodegenerative proteinopathies, such as Alzheimer's disease (AD) and
Parkinson's disease (PD), are characterized by the misfolding and aggregation of toxic …
Parkinson's disease (PD), are characterized by the misfolding and aggregation of toxic …
Convergent molecular defects underpin diverse neurodegenerative diseases
GK Tofaris, NJ Buckley - Journal of Neurology, Neurosurgery & …, 2018 - jnnp.bmj.com
In our ageing population, neurodegenerative disorders carry an enormous personal,
societal and economic burden. Although neurodegenerative diseases are often thought of …
societal and economic burden. Although neurodegenerative diseases are often thought of …
[HTML][HTML] Compensatory mechanisms in genetic models of neurodegeneration: are the mice better than humans?
G Kreiner - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Neurodegenerative diseases are one of the main causes of mental and physical disabilities.
Neurodegeneration has been estimated to begin many years before the first clinical …
Neurodegeneration has been estimated to begin many years before the first clinical …
[HTML][HTML] Drosophila nervous system as a target of aging and anti-aging interventions
LV Omelyanchuk, MV Shaposhnikov… - Frontiers in …, 2015 - frontiersin.org
Nervous system regulates homeostasis and adaptation to environmental changes of a
whole organism, thus deregulation of nervous processes accelerates aging (Alcedo et al …
whole organism, thus deregulation of nervous processes accelerates aging (Alcedo et al …
[HTML][HTML] Unraveling Novel Mechanisms of Neurodegeneration Through a Large-Scale Forward Genetic Screen in Drosophila
SL Deal, S Yamamoto - Frontiers in genetics, 2019 - frontiersin.org
Neurodegeneration is characterized by progressive loss of neurons. Genetic and
environmental factors both contribute to demise of neurons, leading to diverse devastating …
environmental factors both contribute to demise of neurons, leading to diverse devastating …
Pathways to neurodegeneration: lessons learnt from unbiased genetic screens in Drosophila
N Singhal, M Jaiswal - Journal of genetics, 2018 - Springer
Neurodegenerative diseases are a complex set of disorders that are known to be caused by
environmental as well as genetic factors. In the recent past, mutations in a large number of …
environmental as well as genetic factors. In the recent past, mutations in a large number of …
Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants
D Lessing, NM Bonini - Nature Reviews Genetics, 2009 - nature.com
The fruitfly Drosophila melanogaster has enabled significant advances in
neurodegenerative disease research, notably in the identification of genes that are required …
neurodegenerative disease research, notably in the identification of genes that are required …
Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer
ME Fortini, NM Bonini - Trends in Genetics, 2000 - cell.com
The ability of Drosophila genetics to reveal new insights into human neurodegenerative
disease is highlighted not only by mutants in flies that show neuronal cell loss, but also by …
disease is highlighted not only by mutants in flies that show neuronal cell loss, but also by …