African trypanosomes, early diverged eukaryotes and the agents of sleeping sickness, have
several basic cellular processes that are remarkably divergent from those in their …

The mitochondrial respiratory chain is comprised of four different protein complexes (I–IV),
which are responsible for electron transport and generation of proton gradient in the …

Trypanosoma brucei is a unicellular parasite that causes devastating diseases in humans
and animals. It diverged from most other eukaryotes very early in evolution and, as a …

The presence of mitochondrial respiratory complex I in the pathogenic bloodstream stages
of Trypanosoma brucei has been vigorously debated: increased expression of …

The composition of the large, single, mitochondrion (mt) of Trypanosoma brucei was
characterized by MS (2‐D LC‐MS/MS and gel‐LC‐MS/MS) analyses. A total of 2897 …

Trypanosoma brucei use microsomal elongases for de novo synthesis of most of its fatty
acids. In addition, this parasite utilizes an essential mitochondrial type II synthase for …

The contribution of trypanosomatid mitochondrial complex I for energy transduction has long
been debated. Herein, we summarize current knowledge on the composition and relevance …

Although eukaryotic mitochondrial (mt) ribosomes evolved from a putative prokaryotic
ancestor their compositions vary considerably among organisms. We determined the protein …

We have generated a high-confidence mitochondrial proteome (MitoTag) of the
Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a …

The parasitic protozoa Trypanosoma brucei has a complex life cycle. Oxidative
phosphorylation is highly active in the procyclic form but absent from bloodstream cells. The …