Pituitary tumors are among the most common neoplasms in man; they account for
approximately 15% of all primary intracranial lesions (Jagannathan et al., Neurosurg Focus …

INHERITED CAUSES OF ACROMEGALY Recognized syndromes that are associated with
inherited pituitary adenomas include multiple endocrine neoplasia type 1 (MEN1), Carney …

Most pituitary tumors are sporadic, though a few occur with a familial aggregation. Three
distinct syndromes have been recognized to date: multiple endocrine neoplasia, type I (MEN …

Pituitary tumors are rare in childhood and adolescence, with a reported prevalence of up to
one per 1 million children. Only 2–6% of surgically treated pituitary tumors occur in children …

Inherited or familial pituitary tumor syndromes such as multiple endocrine neoplasia type 1
and Carney complex provide an important insight into the genetics and molecular pathology …

Objective Most pituitary tumours occur sporadically without a genetically identifiable
germline abnormality, a small but increasing proportion present with a genetic defect that …

Recently, a number of novel genetic alterations have been identified that predispose
individuals to pituitary adenomas. Clinically relevant pituitary adenomas are relatively …

Objective: To summarize current knowledge on the clinical and genetic characteristics of
familial pituitary tumor syndromes. Methods: This review is based on a comprehensive …

Background Pituitary tumours are usually benign and relatively common intracranial
tumours, with under-and overexpression of pituitary hormones and local mass effects …

According to data derived from autopsy and radiological imaging series, pituitary tumours
occur very commonly in the general population; however, most of these tumours are …