Background Inhaled hypertonic saline (HS) improves lung function and decreases
pulmonary exacerbations in older patients with cystic fibrosis (CF). Initiating therapies in …

Inhaled hypertonic saline (HS) positively affects both lung function and pulmonary
exacerbations in children and adults with cystic fibrosis (CF). Early initiation of treatment may …

Background Inhaled hypertonic saline (HS) is an attractive agent for chronic maintenance
therapy in infants and toddlers with cystic fibrosis (CF) because it improves defective …

Context Inhaled hypertonic saline is recommended as therapy for patients 6 years or older
with cystic fibrosis (CF), but its efficacy has never been evaluated in patients younger than 6 …

Background This crossover, randomized, double-blind study (conducted over a 32-week
period) was performed to determine, in clinically stable Cystic fibrosis (CF) preschool …

Rationale: Cystic fibrosis (CF) lung disease starts in early infancy, suggesting that preventive
treatment may be most beneficial. Lung clearance index (LCI) and chest magnetic …

Background Inhaled hypertonic saline enhances mucociliary clearance, improves lung
function, and reduces pulmonary exacerbations in people with cystic fibrosis older than age …

Background Hypertonic saline (HS) is commonly prescribed for children with cystic fibrosis
(CF) despite the absence of strong data indicating clinical efficacy in a population with mild …

Summary Background In the Saline Hypertonic in Preschoolers (SHIP) study, inhaled 7%
hypertonic saline improved the lung clearance index in children aged 3–6 years with cystic …

Progressive lung disease in patients with cystic fibrosis (CF) is caused by thick secretions,
which cause airway obstruction and subsequent colonization and infection by inhaled …