The Na-K-2Cl cotransporter (NKCC) is a Cl− uptake transporter that is responsible for
maintaining a Cl− equilibrium potential positive to the resting potential in neurons. If NKCC …

The processing of signals by integrative neurons in the retina and CNS relies strongly on
inhibitory synaptic inputs, principally from GABAergic and glycinergic neurons that serve …

Key points• The Cl− uptake cotransporter, Na+–K+–2Cl− type 1 (NKCC1), is expressed in
the distal synaptic layer of the vertebrate retina, where photoreceptor terminals contact the …

A GABA-or glycine-induced increase in Cl− permeability can produce either a depolarization
or hyperpolarization, depending on the Cl− equilibrium potential. It has been shown that …

The neuron-specific K-Cl cotransporter (KCC2) is hypothesized to function as an active Cl−
extrusion pathway important in postsynaptic inhibition mediated by ligand-gated anion …

We examined the expression of the KCC2 isoform of the K‐Cl cotransporter in the
developing and adult brain, using an affinity‐purified antibody directed against a unique …

The fetal human lens epithelial cell (LEC) line (FHL124) possesses all four K+ Cl-(KCC)
cotransporter isoforms, KCC1-4, despite KCC2 being typically considered a neuronal …

Here we describe the expression pattern of the Na-K-2Cl-cotransporter NKKC1 during
embryonal and early postnatal mouse development. During early stages hybridization …

Abstract The Drosophila Ncc69 gene encodes a Na+-K+-2Cl−-cotransporter (NKCC) that is
critical for regulating intra-and extracellular ionic conditions in different tissues. Here, we …

Abstract The electroneutral Na–K–Cl co–transporter (NKCC) protein transports Na+, K+ and
Cl− into cells under physiological conditions with a stoichiometry of 1Na+: 1K+: 2Cl−. NKCC …