Focal cerebral ischemia, known as stroke, is caused by a sudden interruption in the blood
supply to the brain. We attempted to identify peptides that can home to ischemic stroke …

Many practical therapies have been explored as clinical applications for ischemic cerebral
infarction; however, most are still insufficient to treat acute stroke. We show here a potential …

We investigated the effect of the VEGF-mimetic peptide, QK, on ischemic brain damage and
on blood–brain barrier permeability in the rat. QK administered by the …

There is lack of a barrier between CSF and brain, thus peptide that can cross the blood–
cerebrospinal-fluid barrier (BCSFB) will have a greater chance of providing access to the …

Background and Purpose—The neuronal death that accompanies an ischemic stroke has
previously been attributed to a necrotic process. However, numerous studies in …

Traumatic brain injury (TBI) is a major health and socio-economic problem, but no
pharmacological agent is currently approved for the treatment of acute TBI. Thus, there is a …

Background and Purpose Synthetic oligopeptides with amino acid sequences of the lectin
domain of selectin block selectin-mediated cell adhesion in vitro, which may be applied to a …

A tremendous effort has been expended to elucidate the role of apoptotic molecules in
ischemia. However, many agents that target apoptosis, despite their proven efficacy in …

Leukocytes play an important role in the development of ischemia/reperfusion injury. Recent
work in our laboratory has demonstrated that a mixture of synthetic fibronectin peptides to …

The effects of brain-derived peptides (BDP; Cerebrolysin®) upon the amount of brain injury
due to focal brain ischemia were assessed. Male Thomae rats were divided randomly into a …