B cell receptors with certain heavy/light chain pairs predominate in the periphery of anti-DNA
heavy chain transgenic mice while certain other B cell receptors are absent. We wanted to …

To study the relative contributions of clonal deletion, clonal anergy, and receptor editing to
tolerance induction in autoreactive B cells and their dependence on B cell receptor affinity …

The diversity of the B-cell repertoire is important for the development of antibodies to a
multitude of pathogens. However, in the process of generating antibody diversity, B-cells …

Systemic lupus erythematosus (SLE) is a severe autoimmune disease that is characterized
by the production of antinuclear antibodies. In particular, the response against the …

Tolerance to dsDNA is broken in mice with a high-affinity anti-DNA H chain transgene, 56R,
on the C57BL/6 background (B6. 56R). B6. 56R produce more anti-dsDNA Abs than BALBc …

One mechanism by which anti-double stranded (ds) DNA B cells are regulated is anergy.
Multiple phenotypes have been attributed to anergic B cells in various transgenic models …

Anti-DNA antibody is the serological hallmark of systemic lupus erythematosus (SLE). While
antibodies with this specificity may be generated in many individuals, only patients with SLE …

Anti‐DNA knock‐in mice serve as models for studying B cell tolerance mechanisms to a
ubiquitous antigen. We have constructed six strains of double transgenic (C57BL/6× …

Receptor editing is performed by replacement of Vκ genes that contribute to autoreactivity. In
addition, the Cκ locus can be deleted by Vκ rearrangement to intronic or 3′ of Cκ RS …

To determine the fate of anti-DNA antibody-bearing B cells in normal mice, we generated
transgenic mice bearing the heavy (H) and light (L) chain genes of a well-characterized anti …