Vigabatrin was a major drug in the treatment of epilepsy until the discovery that it was
associated with an irreversible constriction of the visual field. Nevertheless, the drug is still …

Epileptic patients experienced an irreversible loss of their peripheral visual field upon
treatment with vigabatrin (gamma‐vinyl GABA), an inhibitor of the GABA degrading enzyme …

Objective Although vigabatrin irreversibly constricts the visual field, it remains a potent
therapy for infantile spasms and a third‐line drug for refractory epilepsies. In albino animals …

The anti-epileptic drug vigabatrin induces an irreversible constriction of the visual field, but is
still widely used to treat infantile spasms and some forms of epilepsy. We recently reported …

Purpose: To determine whether long-term treatment with the anti-epileptic drug vigabatrin
causes damage to rabbit retina. Methods: Five rabbits were treated continuously with a daily …

Abstract Vigabatrin (γ-vinyl-GABA, GVG) is an irreversible inhibitor of GABA-
aminotransferase (GABA-T) that is under clinical trial as an antiepileptic drug. Rats were …

Purpose: Vigabatrin (VGB) is an effective antiepileptic that increases concentrations of
inhibitory γ-aminobutyric acid (GABA) by inhibiting GABA transaminase. Reports of VGB …

Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-
transaminase, effectively halting seizures. Unfortunately, VGB treatment is also associated …

Purpose: Vigabatrin (VGB) is an irreversible inhibitor of γ‐aminobutyric acid (GABA)
transaminase. Its use as an antiepileptic drug (AED) has been limited because it causes …

Background To investigate, in a rabbit model, the effect of two different doses of vigabatrin
(VGB) on retinal function and morphology. Methods Twenty-nine rabbits of mixed strain were …