IGF-I action is essential for the regulation of tissue formation and remodeling, bone growth,
prenatal growth, brain development, and muscle metabolism. Cellular effects of IGF-I are …

Abstract Insulin‐like growth factor‐1 (IGF‐1) plays a central role in cellular growth,
differentiation, survival, and cell cycle progression. It is expressed early during development …

Insulin-like growth factor-I (IGF-I) regulates cell growth, survival, and differentiation by acting
on the IGF-I receptor,(IGF-IR)-a tyrosine kinase receptor, which elicits diverse intracellular …

The importance of the insulin-like growth factor (IGF)-I axis in the regulation of bone size and
bone mineral density, two important determinants of bone strength, has been well …

IGF-I regulates bone acquisition and maintenance, even though the cellular targets and
signaling pathways responsible for its action in human bone cells are poorly understood …

The insulin-like growth factors (IGFs) are the most abundant growth factors stored in bone
and produced by osteoblasts. IGF-I is an important regulator of osteoblast function and …

Osteoporosis, a disorder of skeletal fragility, is common in the elderly, and its prevalence is
increasing as more individuals with low bone mineral density (BMD), the strongest predictor …

Insulin-like growth factor-I (IGF-I) is produced by chondrocytes, osteoblasts, osteocytes, and
osteoclasts, and its receptor (IGF-IR) is found in all of these cells. The actions of IGF-I are …

Insulin‐like growth factor (IGF)‐I is important in the acquisition and maintenance of both soft
and hard tissues. Skeletal remodeling requires energy and recent work has demonstrated …

The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that
regulate multiple physiological processes, including mammalian development, metabolism …