FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated
by PPARα in rodents. However, the physiological role of FGF21 in man is not yet defined …

Context: Murine fibroblast growth factor (FGF) 21 is a nutritionally regulated hormone
secreted by the liver principally in response to peroxisome proliferator-activated receptor-α …

Fibroblast growth factor 21 (FGF21) has recently emerged as a metabolic hormone involved
in regulating glucose and lipid metabolism in mouse, but the regulatory mechanisms and …

The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in
animal models of diabetes and obesity. Using quantitative RT-PCR, we here show that the …

Adipose tissue is a metabolically responsive endocrine organ that secretes a myriad of
adipokines. Antidiabetic drugs such as peroxisome proliferator-activated receptor (PPAR) γ …

Fibroblast growth factor 21 (FGF21) was originally identified as a member of the FGF family
in homology studies and is a member of the endocrine FGF subfamily that lacks heparin …

The FGF family comprises twenty‐two structurally related proteins with functions in
development and metabolism. The Fgf21 gene was generated early in vertebrate evolution …

OBJECTIVE—Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple
beneficial effects on glucose homeostasis and insulin sensitivity in animal models. This …

Summary Fibroblast growth factor 21 (FGF 21), a metabolic hormone predominantly
produced by the liver, is also expressed in adipocytes and the pancreas. It regulates glucose …

Objective Fibroblast-growth factor 21 (FGF21) is thought to be important in metabolic
regulation. Recently, low protein diets have been shown to increase circulating FGF21 …