Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling
The adaptor and signaling proteins TRAF2, TRAF3, cIAP1 and cIAP2 may inhibit alternative
nuclear factor-κB (NF-κB) signaling in resting cells by targeting NF-κB–inducing kinase (NIK) …
nuclear factor-κB (NF-κB) signaling in resting cells by targeting NF-κB–inducing kinase (NIK) …
Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
BJ Zarnegar, Y Wang, DJ Mahoney, PW Dempsey… - Nature …, 2008 - nature.com
Recent studies suggest that nuclear factor κB-inducing kinase (NIK) is suppressed through
constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or …
constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or …
Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF‐κB
H Habelhah, S Takahashi, SG Cho, T Kadoya… - The EMBO …, 2004 - embopress.org
TRAF2 is a RING finger protein that regulates the cellular response to stress and cytokines
by controlling JNK, p38 and NF‐κB signaling cascades. Here, we demonstrate that TRAF2 …
by controlling JNK, p38 and NF‐κB signaling cascades. Here, we demonstrate that TRAF2 …
Targeting signaling factors for degradation, an emerging mechanism for TRAF functions
XD Yang, SC Sun - Immunological reviews, 2015 - Wiley Online Library
Tumor necrosis factor receptor (TNFR)‐associated factors (TRAF s) form a family of proteins
that are best known as signaling adapters of TNFR s. However, emerging evidence …
that are best known as signaling adapters of TNFR s. However, emerging evidence …
PKC phosphorylation of TRAF2 mediates IKKα/β recruitment and K63-linked polyubiquitination
S Li, L Wang, ME Dorf - Molecular cell, 2009 - cell.com
Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key mediator in TNF
signaling. Previous studies suggested that TRAF2 functions as an adaptor in the NF-κB and …
signaling. Previous studies suggested that TRAF2 functions as an adaptor in the NF-κB and …
TRAF2 differentially regulates the canonical and noncanonical pathways of NF-κB activation in mature B cells
AP Grech, M Amesbury, T Chan, S Gardam, A Basten… - Immunity, 2004 - cell.com
To examine the role of the TNF-R superfamily signaling protein TRAF2 in mature B cell
development and NF-κB activation, conditionally TRAF2-deficient mice were produced. B …
development and NF-κB activation, conditionally TRAF2-deficient mice were produced. B …
TRAF6 autoubiquitination-independent activation of the NFκB and MAPK pathways in response to IL-1 and RANKL
MC Walsh, GK Kim, PL Maurizio, EE Molnar, Y Choi - PloS one, 2008 - journals.plos.org
The adapter protein TRAF6 is critical for mediating signal transduction from members of the
IL-1R/TLR and TNFR superfamilies. The TRAF6 RING finger domain functions as an …
IL-1R/TLR and TNFR superfamilies. The TRAF6 RING finger domain functions as an …
Specificity of TRAF3 in its negative regulation of the noncanonical NF-κB pathway
JQ He, SK Saha, JR Kang, B Zarnegar… - Journal of Biological …, 2007 - ASBMB
Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are critical signaling
adaptors downstream of many receptors in the TNF receptor and interleukin-1 receptor/Toll …
adaptors downstream of many receptors in the TNF receptor and interleukin-1 receptor/Toll …
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-κB activation
L He, AC Grammer, X Wu, PE Lipsky - Journal of Biological Chemistry, 2004 - ASBMB
FRET experiments utilizing confocal microscopy or flow cytometry assessed homo-and
heterotrimeric association of human tumor necrosis factor receptor-associated factors …
heterotrimeric association of human tumor necrosis factor receptor-associated factors …