Failure of two commercial indexes and spectral parameters to reflect the pharmacodynamic effect of desflurane on EEG

S Kreuer, J Bruhn, R Ellerkmann, S Ziegeler… - Journal of clinical …, 2008 - Springer
Objective We compared two PK/PD models, one with and one without a plateau effect.
Bispectral (BIS, Aspect Medical Systems, Natick, MA, version XP) and Narcotrend™(NCT …

Comparative pharmacodynamic modeling of desflurane, sevoflurane and isoflurane

S Kreuer, J Bruhn, W Wilhelm, U Grundmann… - Journal of clinical …, 2009 - Springer
Background We compared dose–response curves of the hypnotic effects of desflurane,
sevoflurane and isoflurane. In addition, we analyzed the k e0 values of the different …

Narcotrend or bispectral index monitoring during desflurane-remifentanil anesthesia: a comparison with a standard practice protocol

S Kreuer, J Bruhn, C Stracke, L Aniset… - Anesthesia & …, 2005 - journals.lww.com
IMPLICATIONS: Monitoring the electroencephalogram with Narcotrend or Bispectral Index
during desflurane-remifentanil anesthesia only slightly reduces recovery times when …

Comparative pharmacodynamic modeling using bispectral and narcotrend-index with and without a pharmacodynamic plateau during sevoflurane anesthesia

S Kreuer, J Bruhn, E Walter, R Larsen… - Anesthesia & …, 2008 - journals.lww.com
BACKGROUND: We compared two pharmacodynamic models, one with and one without a
plateau effect. Bispectral indices (BIS, Aspect Medical Systems, Natick, MA, version XP) and …

Approximate entropy as an electroencephalographic measure of anesthetic drug effect during desflurane anesthesia

J Bruhn, H Röpcke, A Hoeft - The Journal of the American Society of …, 2000 - pubs.asahq.org
Background The authors hypothesized that the electroencephalogram (EEG) during higher
anesthetic concentrations would show more" order" and less" randomness" than at lower …

The correlation of the Narcotrend® Index and classical electroencephalographic parameters with endtidal desflurane concentrations and hemodynamic parameters …

F Weber, M Gruber, K Taeger - Pediatric Anesthesia, 2005 - Wiley Online Library
Summary Background: The Narcotrend® Index (NI) for assessment of depth of anesthesia
by analysis of the electroencephalogram (EEG), is potentially a pharmacodynamic measure …

Application of Bispectral index® and Narcotrend® index to the measurement of the electroencephalographic effects of Isoflurane with and without burst suppression

S Kreuer, J Bruhn, R Larsen, U Grundmann… - The Journal of the …, 2004 - pubs.asahq.org
Background The Narcotrend monitor (MonitorTechnik, Bad Bramstedt, Germany) has
recently been introduced as an intraoperative monitor of anesthetic state, based on a …

Surgical stimulation shifts EEG concentration–response relationship of desflurane

H Röpcke, B Rehberg… - The Journal of the …, 2001 - pubs.asahq.org
Background Anesthesiologists routinely increase the delivered anesthetic concentration
before surgical stimulation in anticipation of increased anesthetic requirement to achieve …

Comparison of BIS and AAI as measures of anaesthetic drug effect during desflurane–remifentanil anaesthesia

S Kreuer, J Bruhn, R Larsen, C Bauer… - Acta …, 2004 - Wiley Online Library
Background: Autoregressive modelling with exogenous input of the middle‐latency auditory
evoked potential has been developed for monitoring of anaesthetic depth. This study was …

A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

V Billard, PL Gambus, N Chamoun… - Clinical …, 1997 - Wiley Online Library
Background The effects of anesthetic drugs on electroencephalograms (EEG) have been
studied to develop the EEG as a measure of anesthetic depth. Bispectral analysis is a new …