Colorectal cancer (CRC) is a complex and heterogeneous disease in which genomic
instability and DNA promoter methylation play important roles. The aim of this study was to …

Purpose: The relationship between global hypomethylation, chromosomal instability (CIN),
and microsatellite instability (MSI) remains unclear in colorectal cancer. The aim of this study …

Simple Summary In colorectal cancer (CRC), mutations may occur in short, repeated DNA
sequences, known as microsatellite instability (MSI). Tumor DNA methylation is another …

Methylation of the MLH1 promoter region has been suggested to be a principal mechanism
of gene inactivation in sporadic microsatellite instability (MSI)–positive colorectal carcinoma …

De novo methylation of promoter region CpG islands has been increasingly associated with
transcriptional inactivation of important genes in neoplasia. To study the potential …

A subset of sporadic colon cancers has been shown to have microsatellite instability caused
by an epigenetic inactivation of the MLH1 gene by hypermethylation of the the CpG island in …

Gene silencing through CpG island hypermethylation has been associated with genesis or
progression of frequent microsatellite instability (MSI-H) cancers. To identify novel …

Regional DNA hypermethylation and global DNA hypomethylation are 2 epigenetic
alterations associated with colorectal cancers. However, their correlation with microsatellite …

Background Aberrant DNA methylation has been widely investigated in sporadic colorectal
carcinomas (CRCs), and extensive work has been performed to characterize different …

Abstract Background: The CpG island methylator phenotype (CIMP) with widespread
promoter methylation is a distinct epigenetic phenotype in colorectal cancer, associated with …