Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis
Recent studies indicate that the CXCL12/CXCR4 interaction is involved in several
inflammatory conditions. However, it is unclear whether this interaction has a role in the …
inflammatory conditions. However, it is unclear whether this interaction has a role in the …
The role of CXCR3 in DSS-induced colitis
Inflammatory bowel disease (IBD) is a group of disorders that are characterized by chronic,
uncontrolled inflammation in the intestinal mucosa. Although the aetiopathogenesis is poorly …
uncontrolled inflammation in the intestinal mucosa. Although the aetiopathogenesis is poorly …
CXCR3 axis: role in inflammatory bowel disease and its therapeutic implication
There is a great need for new intervention and prevention strategies against Crohn's
disease (CD), a chronic, relapsing tissue-destructive inflammatory bowel disease (IBD) …
disease (CD), a chronic, relapsing tissue-destructive inflammatory bowel disease (IBD) …
Expression and regulation of the chemokine receptor CXCR3 on lymphocytes from normal and inflammatory bowel disease mucosa
KA Papadakis, J Prehn, D Zhu… - Inflammatory bowel …, 2004 - academic.oup.com
Chemokine receptors play an important role in the recruitment of activated T cells to
inflammatory sites. The aim of this study was to analyze the expression of the chemokine …
inflammatory sites. The aim of this study was to analyze the expression of the chemokine …
[HTML][HTML] Blockade of CXCR2 suppresses proinflammatory activities of neutrophils in ulcerative colitis
F Zhu, H He, L Fan, C Ma, Z Xu, Y Xue… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) is one chronically remittent and progressive inflammatory disorder.
Chemokine receptor CXCR2 is reported to be involved in the pathogenesis of several …
Chemokine receptor CXCR2 is reported to be involved in the pathogenesis of several …
Chemokine receptor CXCR3 expression in inflammatory bowel disease
YH Yuan, T Hove, FO The, JFM Slors… - Inflammatory bowel …, 2001 - academic.oup.com
CD4+ T lymphocytes in the lamina propria (LP) of the gut play a central role in the immune
response in inflammatory bowel disease (IBD). CXCR3 is a chemokine receptor expressed …
response in inflammatory bowel disease (IBD). CXCR3 is a chemokine receptor expressed …
Anti-interferon-inducible chemokine, CXCL10, reduces colitis by impairing T helper-1 induction and recruitment in mice
JG Hyun, G Lee, JB Brown, GR Grimm… - Inflammatory bowel …, 2005 - academic.oup.com
Background Colitis in interleukin (IL)-10−/− mice is a CD4+ T helper 1 (TH1)-mediated
disease characterized by intermittent, transmural inflammation reminiscent of human …
disease characterized by intermittent, transmural inflammation reminiscent of human …
CXCR3 plays a critical role for host protection against Salmonellosis
CXCR3 and its ligands are heavily associated with inflammation and have been implicated
in numerous inflammatory diseases. CXCR3 plays an important role in recruiting pro …
in numerous inflammatory diseases. CXCR3 plays an important role in recruiting pro …
[HTML][HTML] CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis
XM Xia, FY Wang, WA Xu, ZK Wang, J Liu… - World journal of …, 2010 - ncbi.nlm.nih.gov
AIM: To investigate the effects of the chemokine stromal cell-derived factor-1 (CXCL12)
receptor (CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in …
receptor (CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in …
Reciprocal regulation of CXCR4 and CXCR7 in intestinal mucosal homeostasis and inflammatory bowel disease
L Werner, H Elad, E Brazowski… - Journal of leukocyte …, 2011 - academic.oup.com
IBDs are characterized by increased influx of immune cells to the mucosa of genetically
susceptible persons. Cellular migration to injury sites is mediated by chemokines. CXCL12 …
susceptible persons. Cellular migration to injury sites is mediated by chemokines. CXCL12 …