Recent studies indicate that the CXCL12/CXCR4 interaction is involved in several
inflammatory conditions. However, it is unclear whether this interaction has a role in the …

Inflammatory bowel disease (IBD) is a group of disorders that are characterized by chronic,
uncontrolled inflammation in the intestinal mucosa. Although the aetiopathogenesis is poorly …

There is a great need for new intervention and prevention strategies against Crohn's
disease (CD), a chronic, relapsing tissue-destructive inflammatory bowel disease (IBD) …

Chemokine receptors play an important role in the recruitment of activated T cells to
inflammatory sites. The aim of this study was to analyze the expression of the chemokine …

Ulcerative colitis (UC) is one chronically remittent and progressive inflammatory disorder.
Chemokine receptor CXCR2 is reported to be involved in the pathogenesis of several …

CD4+ T lymphocytes in the lamina propria (LP) of the gut play a central role in the immune
response in inflammatory bowel disease (IBD). CXCR3 is a chemokine receptor expressed …

Background Colitis in interleukin (IL)-10−/− mice is a CD4+ T helper 1 (TH1)-mediated
disease characterized by intermittent, transmural inflammation reminiscent of human …

CXCR3 and its ligands are heavily associated with inflammation and have been implicated
in numerous inflammatory diseases. CXCR3 plays an important role in recruiting pro …

AIM: To investigate the effects of the chemokine stromal cell-derived factor-1 (CXCL12)
receptor (CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in …

IBDs are characterized by increased influx of immune cells to the mucosa of genetically
susceptible persons. Cellular migration to injury sites is mediated by chemokines. CXCL12 …