The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis
KD Brown, E Claudio, U Siebenlist - Arthritis research & therapy, 2008 - Springer
Nuclear factor-κB (NF-κB) is an inducible transcription factor controlled by two principal
signaling cascades, each activated by a set of signal ligands: the classical/canonical NF-κB …
signaling cascades, each activated by a set of signal ligands: the classical/canonical NF-κB …
Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?
The nuclear factor-κB (NF-κB) family of transcription factors is essential for the expression of
pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be …
pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be …
Signalling, inflammation and arthritis: NF-κ B and its relevance to arthritis and inflammation
RE Simmonds, BM Foxwell - Rheumatology, 2008 - academic.oup.com
In the synovial cells of patients with RA, activation of the nuclear factor-κB (NF-κB) pathway
results in the transactivation of a multitude of responsive genes that contribute to the …
results in the transactivation of a multitude of responsive genes that contribute to the …
NF-κB in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction
SS Makarov - Arthritis Research & Therapy, 2001 - Springer
The transcription factor NF-κB has been well recognized as a pivotal regulator of
inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad …
inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad …
Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis
IK Campbell, S Gerondakis… - The Journal of …, 2000 - Am Soc Clin Investig
Rheumatoid arthritis (RA) is a complex disease, with contributions from systemic
autoimmunity and local inflammation. Persistent synovial joint inflammation and invasive …
autoimmunity and local inflammation. Persistent synovial joint inflammation and invasive …
[HTML][HTML] NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
JA Roman-Blas, SA Jimenez - Osteoarthritis and cartilage, 2006 - Elsevier
The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the
regulation of expression of numerous genes in the setting of the inflammatory response …
regulation of expression of numerous genes in the setting of the inflammatory response …
Negative regulation of NF-κB and its involvement in rheumatoid arthritis
G van Loo, R Beyaert - Arthritis research & therapy, 2011 - Springer
The transcription factor NF-κB plays crucial roles in the regulation of inflammation and
mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune …
mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune …
Immune deficiency or hyperactivity-Nf-κb illuminates autoimmunity
S Pai, R Thomas - Journal of autoimmunity, 2008 - Elsevier
Nuclear factor (NF)-κB is a transcription factor family which transmits signals from the cell
surface to the nucleus, resulting in transcriptional effects on genes involved in inflammation …
surface to the nucleus, resulting in transcriptional effects on genes involved in inflammation …
Nuclear factor (NF)-κB proteins: therapeutic targets
IM Verma - Annals of the rheumatic diseases, 2004 - ard.bmj.com
Nuclear factor (NF)-kB is a key player in the control of both innate and adaptive immunity. NF-
kB proteins are present in the cytoplasm in association with inhibitory proteins called …
kB proteins are present in the cytoplasm in association with inhibitory proteins called …
The NF-κB signalling pathway in osteoarthritis
S Rigoglou, AG Papavassiliou - The international journal of biochemistry & …, 2013 - Elsevier
Nuclear factor-kappaB (NF-κB) proteins constitute a family of transcription factors that are
stimulated by pro-inflammatory cytokines, chemokines, stress-related factors and …
stimulated by pro-inflammatory cytokines, chemokines, stress-related factors and …
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