Recent advances in the development of novel anti‐cancer drugs targeting cancer stem/progenitor cells
M Mimeault, SK Batra - Drug Development Research, 2008 - Wiley Online Library
Recent advances in basic and clinical oncology have led to the identification and
characterization of several deregulated gene products involved in cancer progression to …
characterization of several deregulated gene products involved in cancer progression to …
Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers
M Mimeault, R Hauke, PP Mehta… - Journal of cellular and …, 2007 - Wiley Online Library
• Introduction• Functions of cancer progenitor cells in the cancer initiation and progression‐
New model of carcinogenesis based on the cancer progenitor cells‐Isolation and ex vitro …
New model of carcinogenesis based on the cancer progenitor cells‐Isolation and ex vitro …
Novel therapies against aggressive and recurrent epithelial cancers by molecular targeting tumor-and metastasis-initiating cells and their progenies
M Mimeault, SK Batra - Anti-Cancer Agents in Medicinal …, 2010 - ingentaconnect.com
A growing body of experimental evidence has revealed that the highly tumorigenic cancer
stem/progenitor cells endowed with stem cell-like properties might be responsible for …
stem/progenitor cells endowed with stem cell-like properties might be responsible for …
[HTML][HTML] Targeting of cancer stem/progenitor cells plus stem cell-based therapies: the ultimate hope for treating and curing aggressive and recurrent cancers
M Mimeault, SK Batra - Panminerva medica, 2008 - ncbi.nlm.nih.gov
The rapid progression from aggressive primary cancers into locally advanced and invasive
and/or metastatic diseases remains a big obstacle for an early diagnosis and curative …
and/or metastatic diseases remains a big obstacle for an early diagnosis and curative …
New promising drug targets in cancer-and metastasis-initiating cells
M Mimeault, SK Batra - Drug discovery today, 2010 - Elsevier
The unique properties of cancer-and metastasis-initiating cells endowed with a high self-
renewal and aberrant differentiation potential (including their elevated expression levels of …
renewal and aberrant differentiation potential (including their elevated expression levels of …
Selective targeting of cancer stem cells: a new concept in cancer therapeutics
Although the concept of 'cancer stem cell'was first proposed more then a century ago, it has
attracted a great deal of attention recently due to advances in stem cell biology, leading to …
attracted a great deal of attention recently due to advances in stem cell biology, leading to …
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery
BBS Zhou, H Zhang, M Damelin, KG Geles… - Nature reviews Drug …, 2009 - nature.com
The hypothesis that cancer is driven by tumour-initiating cells (popularly known as cancer
stem cells) has recently attracted a great deal of attention, owing to the promise of a novel …
stem cells) has recently attracted a great deal of attention, owing to the promise of a novel …
Cancer stem cell targeting: are we there yet?
Several decades after the first notion that cancer cells are heterogeneous, not only
histologically but also at the level of tumorigenicity, the existence of a tumor initiation …
histologically but also at the level of tumorigenicity, the existence of a tumor initiation …
[HTML][HTML] New advances on critical implications of tumor-and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence
M Mimeault, SK Batra - Histology and histopathology, 2010 - ncbi.nlm.nih.gov
Accumulating lines of experimental evidence have revealed that the malignant
transformation of multipotent tissue-resident adult stem/progenitor cells into cancer …
transformation of multipotent tissue-resident adult stem/progenitor cells into cancer …
Cancer stem cells and cellular plasticity: A preface to the special issue “Advances in understanding cancer stem cell biology and perspectives for targeted therapy”
FAE Kruyt - Biochemical Pharmacology, 2023 - Elsevier
The basis of the cancer stem cell concept had already been coined in the 19th century by
the time the German pathologists, Virchow and Cohnheim, proposed the 'embryonic origin of …
the time the German pathologists, Virchow and Cohnheim, proposed the 'embryonic origin of …