Recent advances in basic and clinical oncology have led to the identification and
characterization of several deregulated gene products involved in cancer progression to …

• Introduction• Functions of cancer progenitor cells in the cancer initiation and progression‐
New model of carcinogenesis based on the cancer progenitor cells‐Isolation and ex vitro …

A growing body of experimental evidence has revealed that the highly tumorigenic cancer
stem/progenitor cells endowed with stem cell-like properties might be responsible for …

The rapid progression from aggressive primary cancers into locally advanced and invasive
and/or metastatic diseases remains a big obstacle for an early diagnosis and curative …

The unique properties of cancer-and metastasis-initiating cells endowed with a high self-
renewal and aberrant differentiation potential (including their elevated expression levels of …

Although the concept of 'cancer stem cell'was first proposed more then a century ago, it has
attracted a great deal of attention recently due to advances in stem cell biology, leading to …

The hypothesis that cancer is driven by tumour-initiating cells (popularly known as cancer
stem cells) has recently attracted a great deal of attention, owing to the promise of a novel …

Several decades after the first notion that cancer cells are heterogeneous, not only
histologically but also at the level of tumorigenicity, the existence of a tumor initiation …

Accumulating lines of experimental evidence have revealed that the malignant
transformation of multipotent tissue-resident adult stem/progenitor cells into cancer …

The basis of the cancer stem cell concept had already been coined in the 19th century by
the time the German pathologists, Virchow and Cohnheim, proposed the 'embryonic origin of …