Discovering microRNAs from deep sequencing data using miRDeep

MR Friedländer, W Chen, C Adamidi, J Maaskola… - Nature …, 2008 - nature.com
The capacity of highly parallel sequencing technologies to detect small RNAs at
unprecedented depth suggests their value in systematically identifying microRNAs …

miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades

MR Friedländer, SD Mackowiak, N Li… - Nucleic acids …, 2012 - academic.oup.com
Abstract microRNAs (miRNAs) are a large class of small non-coding RNAs which post-
transcriptionally regulate the expression of a large fraction of all animal genes and are …

mirTools: microRNA profiling and discovery based on high-throughput sequencing

E Zhu, F Zhao, G Xu, H Hou, LL Zhou, X Li… - Nucleic acids …, 2010 - academic.oup.com
Abstract miRNAs are small, non-coding RNA that negatively regulate gene expression at
post-transcriptional level, which play crucial roles in various physiological and pathological …

MIReNA: finding microRNAs with high accuracy and no learning at genome scale and from deep sequencing data

A Mathelier, A Carbone - Bioinformatics, 2010 - academic.oup.com
Motivation: MicroRNAs (miRNAs) are a class of endogenes derived from a precursor (pre-
miRNA) and involved in post-transcriptional regulation. Experimental identification of novel …

Identification of novel and known miRNAs in deep‐sequencing data with miRDeep2

SD Mackowiak - Current protocols in bioinformatics, 2011 - Wiley Online Library
Abstract miRNAs comprise an abundant class of small non‐coding RNAs that play important
roles in a wide range of biological processes by post‐transcriptional regulation of a large …

[HTML][HTML] Next generation sequencing of miRNAs–strategies, resources and methods

S Motameny, S Wolters, P Nürnberg, B Schumacher - Genes, 2010 - mdpi.com
miRNAs constitute a family of small RNA species that have been demonstrated to play a
central role in regulating gene expression in many organisms. With the advent of next …

Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues

L Castellano, J Stebbing - Nucleic acids research, 2013 - academic.oup.com
MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression. They are
characterized by specific maturation processes defined by canonical and non-canonical …

miRBase: annotating high confidence microRNAs using deep sequencing data

A Kozomara, S Griffiths-Jones - Nucleic acids research, 2014 - academic.oup.com
We describe an update of the miRBase database (http://www. mirbase. org/), the primary
microRNA sequence repository. The latest miRBase release (v20, June 2013) contains 24 …

miRDeep*: an integrated application tool for miRNA identification from RNA sequencing data

J An, J Lai, ML Lehman, CC Nelson - Nucleic acids research, 2013 - academic.oup.com
Abstract miRDeep and its varieties are widely used to quantify known and novel micro RNA
(miRNA) from small RNA sequencing (RNAseq). This article describes miRDeep*, our …

Approaches to microRNA discovery

E Berezikov, E Cuppen, RHA Plasterk - Nature genetics, 2006 - nature.com
MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several
hundred genes encoding miRNAs have been experimentally identified in animals, and …