Huntington's disease (HD) is caused by an extended polyglutamine (polyQ) tract in the
Huntingtin protein. Neuronal and glial dysfunction precedes the neurodegeneration and …

HD (Huntington's disease) is a fatal inherited gain-of-function disorder caused by a polyQ
(polyglutamine) expansion in the htt (huntingtin protein). Expression of mutant htt in model …

Expanded polyglutamine (polyQ) proteins in Huntington's disease (HD) as well as other
polyQ disorders are known to elicit a variety of intracellular toxicities, but it remains unclear …

Abstract Spinocerebellar Ataxia type 1 (SCA1) and Huntington's disease (HD) are two
polyglutamine disorders caused by expansion of a CAG repeat within the coding regions of …

Huntington disease is caused by polyglutamine expansion in huntingtin, a 350kD protein
that is ubiquitously expressed and widely distributed at the subcellular level. Recently …

A number of mouse models expressing mutant huntingtin (htt) with an expanded
polyglutamine (polyQ) domain are useful for studying the pathogenesis of Huntington's …

Huntington disease (HD) is an inherited neurodegenerative disorder caused by a
polyglutamine (polyQ) expansion in the huntingtin (Htt) gene. Despite years of research …

Huntington's disease (HD) is caused by the expansion of the polyglutamine (polyQ) tract in
the human Huntingtin (hHtt) protein (polyQ-hHtt). Although this mutation behaves …

The isolation of the Huntington's disease (HD) gene in 1993 (Huntington's Disease
Collaborative Research Group 1993) made it possible to generate in vivo genetic models of …

Poly-glutamine expansion near the N-terminus of the huntingtin protein (HTT) is the prime
determinant of Huntington's disease (HD) pathology; however, post-translational …