Genetic deletion or pharmacological blockade of the CB1 receptor has been reported to
impair extinction learning in aversive conditioning (ie, conditioned fear and Morris water …

CB1 receptor-compromised animals show profound deficits in extinguishing learned
behavior from aversive conditioning tasks, but display normal extinction learning in …

Rationale A growing body of in vitro and in vivo evidence indicates that a central
endocannabinoid system, consisting of CB 1 receptors and endogenous cannabinoids …

Recent reports have demonstrated that disruption of CB 1 receptor signaling impairs
extinction of learned responses in conditioned fear and Morris water maze paradigms. Here …

Rationale Disruption of CB 1 receptor signaling through the use of CB 1 (−/−) mice or the CB
1 receptor antagonist rimonabant (SR141716) has been demonstrated to impair extinction of …

For more than a decade, a considerable amount of research has examined the effects of
rimonabant (SR 141716) and other CB1 receptor antagonists in both in vivo and in vitro …

The endocannabinoid system has been proposed to modulate a variety of physiological
processes, including those that underlie cognition. The present study tested whether this …

Thesis under the direction of Robert Hampson, Ph. D., Associate Professor of Physiology
and Pharmacology It has been established that the administration of Δ9-THC and other …

Cannabinoids have long been associated with mnemonic deficits. However, existing
evidence has generally focused on the effect of cannabinoids when they are delivered prior …

Chronic and acute agonism as well as acute antagonism of CB1 receptors reveal
modulation of learning and memory during stable performance of a delayed-nonmatch-to …