Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell …

Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB
proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to …

The inhibitor of nuclear factor‐κB (IκB) kinase (IKK) complex is the master regulator of the NF‐
κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly …

A critical step in the activation of NF-κB is the phosphorylation of IκBs by the IκB kinase (IKK)
complex. IKKα and IKKβ are the two catalytic subunits of the IKK complex and two additional …

The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …

Activation of the transcription factor NF-κB is controlled by the sequential phosphorylation,
ubiquitination, and degradation of its inhibitory subunit, IκB. We recently purified a large …

IKKβ/IKBKB (IκB kinase beta), also designated as IKK2, was named after its function of
phosphorylating IκB molecules, the inhibitors of NF-κB transcription factors. The kinase …

Copyright 2000 Academic PressNF-κB is a heterodimeric transcription factor that plays a key
role in inflammatory and immune responses. In non-stimulated cells, NF-κB dimers are …

The NF-κB family of transcription factors plays a crucial role in the immune, inflammatory and
apoptotic responses. These proteins are normally found in the cytoplasm, retained by …

The IKK kinase complex is the core element of the NF-κB cascade. It is essentially made of
two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. Additional components …