Attention-deficit/hyperactivity disorder, Tourette's syndrome, and restless legs syndrome: the iron hypothesis

S Cortese, M Lecendreux, B Dalla Bernardina… - Medical …, 2008 - Elsevier
Preliminary but increasing evidence suggests that attention-deficit/hyperactivity disorder
(ADHD), Tourette's syndrome (TS), and restless legs syndrome (RLS) may be comorbid. In …

Impact of restless legs syndrome and iron deficiency on attention-deficit/hyperactivity disorder in children

E Konofal, S Cortese, M Marchand, MC Mouren… - Sleep medicine, 2007 - Elsevier
OBJECTIVE: Increasing evidence suggests a significant comorbidity between attention-
deficit/hyperactivity disorder (ADHD) and restless legs syndrome (RLS). Iron deficiency may …

Iron and attention deficit/hyperactivity disorder: What is the empirical evidence so far? A systematic review of the literature

S Cortese, M Angriman, M Lecendreux… - Expert review of …, 2012 - Taylor & Francis
The authors systematically reviewed evidence on iron status, as well as studies of iron
supplementation, in individuals with attention deficit/hyperactivity disorder (ADHD). PubMed …

Association between low serum ferritin and restless legs syndrome in patients with attention deficit hyperactivity disorder

P Oner, EB Dirik, Y Taner, A Caykoylu… - The Tohoku journal of …, 2007 - jstage.jst.go.jp
Low Serum Ferritin and Restless Legs Syndrome in Patients with Attention Deficit
Hyperactivity Disorder. Tohoku J. Exp. Med., 2007, 213 (3), 269-276── Attention defi cit …

Is iron deficiency an underlying cause of pediatric restless legs syndrome and of attention-deficit/hyperactivity disorder?

D Picchietti - 2007 - psycnet.apa.org
This editorial comments on an article by Konofal et al (see record 2007-19316-003). The
authors provide us with important new data on iron, restless legs (RLS), and attention …

Brain iron concentrations in the pathophysiology of children with attention deficit/hyperactivity disorder: a systematic review

A Degremont, R Jain, E Philippou… - Nutrition …, 2021 - academic.oup.com
Context Attention deficit/hyperactivity disorder (ADHD) is a neurological disorder associated
with iron dysregulation in children. Although previous focus was on examining systemic iron …

Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome

FH Khan, CD Ahlberg, CA Chow, DR Shah, BB Koo - Journal of neurology, 2017 - Springer
Restless legs syndrome (RLS) is a common, chronic neurologic condition, which causes a
persistent urge to move the legs in the evening that interferes with sleep. Human and animal …

Brain iron levels in attention-deficit/hyperactivity disorder: a pilot MRI study

S Cortese, R Azoulay, FX Castellanos… - The World Journal of …, 2012 - Taylor & Francis
Objective. Brain iron deficiency has been supposed to be involved in the pathophysiology of
ADHD. Available studies assessing iron in ADHD are based on serum ferritin, a peripheral …

Thy1 expression in the brain is affected by iron and is decreased in Restless Legs Syndrome

X Wang, J Wiesinger, J Beard, B Felt, S Menzies… - Journal of the …, 2004 - Elsevier
Thy-1 is a cell adhesion molecule that plays a regulatory role in the vesicular release of
neurotransmitters. The objective of this study is to examine the relationship between iron …

Sleep disturbances and serum ferritin levels in children with attention-deficit/hyperactivity disorder

S Cortese, E Konofal, BD Bernardina… - European child & …, 2009 - Springer
Background A subset of children with attention-deficit/hyperactivity disorder (ADHD) may
present with impairing sleep disturbances. While preliminary evidence suggests that iron …