Once a rarely used subset of medical treatments, protein therapeutics have increased
dramatically in number and frequency of use since the introduction of the first recombinant …

The discovery of insulin is one of the greatest milestones in medical history. This discovery
revolutionized the use of peptides and proteins as therapeutic agents. For more than six …

We are on the brink of a therapeutic revolution. There research as well as recent
developments in the use of more established peptide therapies. has been a rapid expansion …

Many of the structural properties of insulin have evolved in response to the requirements of
biosynthesis, processing, transport and storage in the pancreatic beta cells, properties that …

Since the approval of insulin in 1982, more than 120 recombinant drug substances have
been approved and become available as extremely valuable therapeutic options. Exact …

At the time of its first clinical application 100 years ago, insulin was presented as the cure for
people with diabetes mellitus. That transpired to be an overstatement, yet insulin has proven …

Insulin remains indispensable in the treatment of diabetes, but its use is hampered by its
narrow therapeutic index. Although advances in peptide chemistry and recombinant DNA …

Recombinant proteins are produced for various applications in laboratory and industrial
settings. Among them, therapeutic applications have evolved into a mature field in recent …

Throughout much of the last century insulin served a central role in the advancement of
peptide chemistry, pharmacology, cell signaling and structural biology. These discoveries …

Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …