A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis
C Labbaye, I Spinello, MT Quaranta, E Pelosi… - Nature Cell …, 2008 - nature.com
MicroRNAs (miRNAs or miRs) regulate diverse normal and abnormal cell functions. We
have identified a regulatory pathway in normal megakaryopoiesis, involving the PLZF …
have identified a regulatory pathway in normal megakaryopoiesis, involving the PLZF …
MicroRNA expression in maturing murine megakaryocytes
JB Opalinska, A Bersenev, Z Zhang… - Blood, The Journal …, 2010 - ashpublications.org
MicroRNAs are small noncoding RNAs that regulate cellular development by interfering with
mRNA stability and translation. We examined global microRNA expression during the …
mRNA stability and translation. We examined global microRNA expression during the …
[HTML][HTML] MicroRNA-146a disrupts hematopoietic differentiation and survival
DT Starczynowski, F Kuchenbauer, J Wegrzyn… - Experimental …, 2011 - Elsevier
OBJECTIVE: MicroRNAs (miRNAs) are short noncoding RNAs capable of exerting dramatic
effects by postranscriptionally regulating numerous messenger RNA targets. Toll-like …
effects by postranscriptionally regulating numerous messenger RNA targets. Toll-like …
A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPα regulates human granulopoiesis
F Fazi, A Rosa, A Fatica, V Gelmetti, ML De Marchis… - Cell, 2005 - cell.com
MicroRNAs play important roles in cell differentiation by acting as translational inhibitors of
specific target genes. Here we show that human granulocytic differentiation is controlled by …
specific target genes. Here we show that human granulocytic differentiation is controlled by …
The regulatory roles of microRNA-146b-5p and its target platelet-derived growth factor receptor α (PDGFRA) in erythropoiesis and megakaryocytopoiesis
Emerging evidence has shown that microRNAs have key roles in regulating various normal
physiological processes, whereas their deregulated expression is correlated with various …
physiological processes, whereas their deregulated expression is correlated with various …
MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia
XS Wang, JN Gong, J Yu, F Wang… - Blood, The Journal …, 2012 - ashpublications.org
Although microRNAs (miRNAs) are increasingly linked to various physiologic processes,
including hematopoiesis, their function in the myeloid development is poorly understood. We …
including hematopoiesis, their function in the myeloid development is poorly understood. We …
Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression
G Zardo, A Ciolfi, L Vian, LM Starnes… - Blood, The Journal …, 2012 - ashpublications.org
Epigenetic modifications regulate developmental genes involved in stem cell identity and
lineage choice. NFI-A is a posttranscriptional microRNA-223 (miR-223) target directing …
lineage choice. NFI-A is a posttranscriptional microRNA-223 (miR-223) target directing …
MicroRNA fingerprints during human megakaryocytopoiesis
R Garzon, F Pichiorri, T Palumbo… - Proceedings of the …, 2006 - National Acad Sciences
microRNAs are a highly conserved class of noncoding RNAs with important regulatory
functions in proliferation, apoptosis, development, and differentiation. To discover novel …
functions in proliferation, apoptosis, development, and differentiation. To discover novel …
Small RNAs guide hematopoietic cell differentiation and function
F Navarro, J Lieberman - The Journal of Immunology, 2010 - journals.aai.org
MicroRNAs (miRNAs) are key regulators of gene expression that help direct normal
differentiation and malignant transformation of hematopoietic cells. This review summarizes …
differentiation and malignant transformation of hematopoietic cells. This review summarizes …
The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression
P Wong, M Iwasaki, TCP Somervaille, F Ficara… - Cancer research, 2010 - AACR
Despite advances in defining the critical molecular determinants for leukemia stem cell
(LSC) generation and maintenance, little is known about the roles of microRNAs in LSC …
(LSC) generation and maintenance, little is known about the roles of microRNAs in LSC …