An essential role for SRC-activated STAT-3 in 14, 15-EET–induced VEGF expression and angiogenesis
SY Cheranov, M Karpurapu, D Wang… - Blood, The Journal …, 2008 - ashpublications.org
To understand the molecular mechanisms underlying 14, 15-epoxyeicosatrienoic acid (14,
15-EET)–induced angiogenesis, here we have studied the role of signal transducer and …
15-EET)–induced angiogenesis, here we have studied the role of signal transducer and …
15(S)-Hydroxyeicosatetraenoic Acid–Induced Angiogenesis Requires STAT3-Dependent Expression of VEGF
K Srivastava, V Kundumani-Sridharan, B Zhang… - Cancer research, 2007 - AACR
Abstract 15 (S)-Hydroxyeicosatetraenoic acid [15 (S)-HETE] activated signal transducer and
activator of transcription 3 (STAT3) as measured by its tyrosine phosphorylation …
activator of transcription 3 (STAT3) as measured by its tyrosine phosphorylation …
15 (S)-hydroxyeicosatetraenoic acid–induced angiogenesis requires Src-mediated Egr-1–dependent rapid induction of FGF-2 expression
V Kundumani-Sridharan, J Niu, D Wang… - Blood, The Journal …, 2010 - ashpublications.org
To understand the mechanisms underlying 15 (S)-hydroxyeicosatetraenoic acid [15 (S)-
HETE]–induced angiogenesis, we studied the role of Egr-1. 15 (S)-HETE induced Egr-1 …
HETE]–induced angiogenesis, we studied the role of Egr-1. 15 (S)-HETE induced Egr-1 …
[HTML][HTML] 5 (S)-hydroxyeicosatetraenoic acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and phosphatidylinositol 3 …
ZZ Zeng, CR Yellaturu, I Neeli, GN Rao - Journal of Biological Chemistry, 2002 - ASBMB
To understand the role of eicosanoids in angiogenesis, we have studied the effect of
lipoxygenase metabolites of arachidonic acid on human microvascular endothelial cell …
lipoxygenase metabolites of arachidonic acid on human microvascular endothelial cell …
[HTML][HTML] Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14, 15-epoxyeicosatrienoic acid-induced angiogenesis
B Zhang, H Cao, GN Rao - Journal of Biological Chemistry, 2006 - ASBMB
To determine the efficacy of cytochrome P450 2C9 metabolites of arachidonic acid, viz. 5, 6-,
8, 9-, 11, 12-, and 14, 15-epoxyeicosatrienoic acids (EETs), in inducing angiogenesis, we …
8, 9-, 11, 12-, and 14, 15-epoxyeicosatrienoic acids (EETs), in inducing angiogenesis, we …
15(S)-Hydroxyeicosatetraenoic Acid Induces Angiogenesis via Activation of PI3K-Akt-mTOR-S6K1 Signaling
B Zhang, H Cao, GN Rao - Cancer research, 2005 - AACR
To determine whether the lipoxygenase metabolites of arachidonic acid, 5 (S)-, 12 (S)-, and
15 (S)-hydroxyeicosatetraenoic acids [5 (S)-HETE, 12 (S)-HETE, and 15 (S)-HETE …
15 (S)-hydroxyeicosatetraenoic acids [5 (S)-HETE, 12 (S)-HETE, and 15 (S)-HETE …
[HTML][HTML] AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15 (S)-hydroxyeicosatetraenoic acid-induced angiogenesis
NK Singh, D Van Quyen… - Journal of Biological …, 2010 - ASBMB
To understand the involvement of matrix metalloproteinases (MMPs) in 15 (S)-
hydroxyeicosatetraenoic acid (15 (S)-HETE)-induced angiogenesis, we have studied the …
hydroxyeicosatetraenoic acid (15 (S)-HETE)-induced angiogenesis, we have studied the …
[HTML][HTML] 15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 …
NK Singh, D Wang, V Kundumani-Sridharan… - Journal of Biological …, 2011 - ASBMB
To understand the mechanisms by which 15 (S)-hydroxyeicosatetraenoic acid (15 (S)-
HETE) activates signal transducer and activator of transcription 3 (STAT3), we studied the …
HETE) activates signal transducer and activator of transcription 3 (STAT3), we studied the …
CREB-mediated IL-6 expression is required for 15 (S)-hydroxyeicosatetraenoic acid–induced vascular smooth muscle cell migration
KR Chava, M Karpurapu, D Wang… - … , and vascular biology, 2009 - Am Heart Assoc
Objective—Migration of vascular smooth muscle cells (VSMCs) from media to intima is a key
event in the pathophysiology of atherosclerosis and restenosis. The lipoxygenase products …
event in the pathophysiology of atherosclerosis and restenosis. The lipoxygenase products …
[HTML][HTML] Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis
We have previously reported that 14, 15-epoxyeicosatrienoic acid (14, 15-EET) is a potent
mitogen for the renal epithelial cell line, LLCPKcl4. This mitogenic effect is dependent upon …
mitogen for the renal epithelial cell line, LLCPKcl4. This mitogenic effect is dependent upon …