Objectives: To review 1. the animal and human experimental evidence that implicates
disordered sleep/wake physiology in the etiology of widespread pain and fatigue and 2. the …

Publisher Summary This chapter reviews the research evidence of the bidirectional relation.
Current models of pain processing and modulation are briefly discussed as background for …

C hronic fatigue syndrome (CFS) and fibromyalgia (FM) are chronic clinical conditions
characterized by a variety of nonspecific somatic complaints. The two most prominent are …

Sleep disturbance is an important clinical complaint for individuals with nonmalignant pain
conditions. This review is a broad introduction to the literature on sleep disturbance and …

Fibromyalgia is a common cause of chronic widespread pain, characterized by reduced
pressure pain thresholds with hyperalgesia and allodynia. In addition to pain, common …

Disturbed sleep is a key complaint of people experiencing acute and chronic pain. These
two vital functions, sleep and pain, interact in complex ways that ultimately impact the …

Patients diagnosed with somatic symptom disorders often report local as well as generalized
pain, fatigue, and sleep disturbance along with other symptoms. Sleep disorders like …

Abstract Purpose of Review The purpose of this review is to present an overview of common
sleep disturbance pathologies and their impact on chronic pain, while examining various …

Noxious stimuli and painful disorders interfere with sleep, but disturbances in sleep also
contribute to the experience of pain. Chronic paroxysmal hemicrania and possibly cluster …

This chapter provides a historical perspective of the notion that the sleeping–waking brain is
intimately related to complaints of unrefreshing sleep, widespread musculoskeletal pain …