Objectives: To determine the steady-state serum and alveolar concentrations of piperacillin/
tazobactam administered in continuous infusion to critically ill patients with ventilator …

Objective To determine the steady-state plasma and epithelial lining fluid (ELF)
concentrations of piperacillin/tazobactam (P/T) administered to critically ill patients with …

Ventilator-associated pneumonia (VAP) occurs in nearly one-third of mechanically ventilated
patients in the Intensive Care Unit. Piperacillin/tazobactam (TZP) is currently recommended …

Pulmonary infections in critically ill patients are common and are associated with high
morbidity and mortality. Piperacillin–tazobactam is a frequently used therapy in critically ill …

The penetration of piperacillin-tazobactam in eight mechanically ventilated intensive care
patients (age, 56.0+/-12.2 years, and weight, 76.5+/-15.2 kg [means+/-standard deviations]) …

Results: Sex, age, Acute Physiology and Chronic Health Evaluation II II score on ICU
admission, diagnosis and underlying disease of VAP patients were not significantly different …

Objective: Obesity and critical illness modify pharmacokinetics of antibiotics, but piperacillin-
tazobactam continuous IV infusion pharmacokinetics has been poorly studied in obese …

The standard mode of administration of piperacillin treatment is by intermittent infusion.
However, continuous infusion may be advantageous as β-lactam antibiotics exhibit time …

Background Severe infections of the respiratory tracts of critically ill patients are common
and associated with excess morbidity and mortality. Piperacillin is commonly used to treat …

In a randomized trial conducted in 27 intensive care units, we compared the clinical efficacy
and safety of piperacillin-tazobactam (TAZ; 4 g/0.5 g qid) and of ceftazidime (CAZ; 1 g qid) …