Transcriptional activation of human telomerase reverse transcriptase (hTERT) is critical for
telomerase expression, a major step for cellular immortality and carcinogenesis. Although …

Telomerase expression is repressed in most somatic cells but is observed in stem cells and
a high percentage of human cancers and has been hypothesized to contribute to …

Telomerase activity in cancer cells is dependent on the transcriptional regulation of the
human telomerase reverse transcriptase (hTERT) gene, encoding the catalytic subunit of …

Multiple endocrine neoplasia type 1 is an autosomal dominant cancer predisposition
syndrome caused by mutations in the tumor‐suppressor gene MEN1. The gene encodes a …

Transcriptional activation of the human telomerase reverse transcriptase (hTERT) gene,
which remains repressed in adult somatic cells, is critical during tumorigenesis. Several …

Telomerase activity is present in most malignant tumors and provides a mechanism for the
unlimited potential for division of neoplastic cells. Although telomerase is known to be a …

Activation of telomerase, which has been frequently associated with cellular immortality, may
constitute a key step in the development of human cancer. De-repression in the expression …

Malignant transformation from mortal, normal cells to immortal, cancer cells is generally
associated with activation of telomerase and subsequent telomere maintenance. A major …

Higher expression of human telomerase reverse transcriptase (hTERT) and subsequent
activation of telomerase occur during cellular immortalization and are maintained in cancer …

Telomerase activation is a critical step for human carcinogenesis through the maintenance
of telomeres, but the activation mechanism during carcinogenesis remains unclear …