Role of menin in the regulation of telomerase activity in normal and cancer cells
M Hashimoto, S Kyo, X Hua… - International …, 2008 - spandidos-publications.com
Transcriptional activation of human telomerase reverse transcriptase (hTERT) is critical for
telomerase expression, a major step for cellular immortality and carcinogenesis. Although …
telomerase expression, a major step for cellular immortality and carcinogenesis. Although …
[HTML][HTML] Multiple tumor suppressor pathways negatively regulate telomerase
SY Lin, SJ Elledge - Cell, 2003 - cell.com
Telomerase expression is repressed in most somatic cells but is observed in stem cells and
a high percentage of human cancers and has been hypothesized to contribute to …
a high percentage of human cancers and has been hypothesized to contribute to …
HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene
M Borowiak, AS Kuhlmann, S Girard, L Gazzolo… - …, 2013 - academic.oup.com
Telomerase activity in cancer cells is dependent on the transcriptional regulation of the
human telomerase reverse transcriptase (hTERT) gene, encoding the catalytic subunit of …
human telomerase reverse transcriptase (hTERT) gene, encoding the catalytic subunit of …
MEN1 tumor‐suppressor protein localizes to telomeres during meiosis
K Suphapeetiporn, JM Greally… - Genes …, 2002 - Wiley Online Library
Multiple endocrine neoplasia type 1 is an autosomal dominant cancer predisposition
syndrome caused by mutations in the tumor‐suppressor gene MEN1. The gene encodes a …
syndrome caused by mutations in the tumor‐suppressor gene MEN1. The gene encodes a …
[HTML][HTML] Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashion
Transcriptional activation of the human telomerase reverse transcriptase (hTERT) gene,
which remains repressed in adult somatic cells, is critical during tumorigenesis. Several …
which remains repressed in adult somatic cells, is critical during tumorigenesis. Several …
Estrogen activates telomerase
S Kyo, M Takakura, T Kanaya, W Zhuo, K Fujimoto… - Cancer research, 1999 - AACR
Telomerase activity is present in most malignant tumors and provides a mechanism for the
unlimited potential for division of neoplastic cells. Although telomerase is known to be a …
unlimited potential for division of neoplastic cells. Although telomerase is known to be a …
Identification of Mad as a repressor of the human telomerase (hTERT) gene
S Oh, YH Song, J Yim, TK Kim - Oncogene, 2000 - nature.com
Activation of telomerase, which has been frequently associated with cellular immortality, may
constitute a key step in the development of human cancer. De-repression in the expression …
constitute a key step in the development of human cancer. De-repression in the expression …
Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms
I Horikawa, JC Barrett - Carcinogenesis, 2003 - academic.oup.com
Malignant transformation from mortal, normal cells to immortal, cancer cells is generally
associated with activation of telomerase and subsequent telomere maintenance. A major …
associated with activation of telomerase and subsequent telomere maintenance. A major …
Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells
Higher expression of human telomerase reverse transcriptase (hTERT) and subsequent
activation of telomerase occur during cellular immortalization and are maintained in cancer …
activation of telomerase occur during cellular immortalization and are maintained in cancer …
Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers
S Kyo, M Takakura, T Fujiwara, M Inoue - Cancer science, 2008 - Wiley Online Library
Telomerase activation is a critical step for human carcinogenesis through the maintenance
of telomeres, but the activation mechanism during carcinogenesis remains unclear …
of telomeres, but the activation mechanism during carcinogenesis remains unclear …