Histone acetyltransferase inhibitors and preclinical studies
F Manzo, FP Tambaro, A Mai… - Expert opinion on …, 2009 - Taylor & Francis
Background: Drugs able to regulate the histone modifier enzymes are very promising tools
for the treatment of several diseases, such as cancer. Histone acetyltransferase (HAT) …
for the treatment of several diseases, such as cancer. Histone acetyltransferase (HAT) …
Targeting JAK/STAT signaling pathway in inflammatory diseases
CJ Malemud, E Pearlman - Current Signal Transduction …, 2009 - ingentaconnect.com
In immune-mediated chronic inflammation the balance between pro-inflammatory and anti-
inflammatory cytokines is skewed so that elevated levels of circulating pro-inflammatory …
inflammatory cytokines is skewed so that elevated levels of circulating pro-inflammatory …
Bisubstrate inhibitors of the MYST HATs Esa1 and Tip60
Esa1 (essential Sas2-related acetyltransferase 1) and Tip60 (HIV-1 TAT-interactive protein,
60kDa) are key members of the MYST family of histone acetyltransferases (HATs) and play …
60kDa) are key members of the MYST family of histone acetyltransferases (HATs) and play …
The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity
ML Hansson, AE Popko-Ścibor… - Nucleic acids …, 2009 - academic.oup.com
MAML1 is a transcriptional coregulator originally identified as a Notch coactivator. MAML1 is
also reported to interact with other coregulator proteins, such as CDK8 and p300, to …
also reported to interact with other coregulator proteins, such as CDK8 and p300, to …
[HTML][HTML] Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts
Abstract Histone acetyltransferases (HATs), p300 and cAMP response element binding
protein (CREB)-binding protein (CBP) are two structurally related transcriptional co …
protein (CREB)-binding protein (CBP) are two structurally related transcriptional co …
Role of chromatin during herpesvirus infections
SB Kutluay, SJ Triezenberg - Biochimica et Biophysica Acta (BBA)-General …, 2009 - Elsevier
DNA viruses have long served as model systems to elucidate various aspects of eukaryotic
gene regulation, due to their ease of manipulation and relatively low complexity of their …
gene regulation, due to their ease of manipulation and relatively low complexity of their …
Complexes of HIV‐1 integrase with HAT proteins: Multiscale models, dynamics, and hypotheses on allosteric sites of inhibition
A new and very promising strategy for HIV drug discovery consists in blocking the multiple
functional interactions between HIV‐1 integrase (IN) and its cellular cofactors. At present …
functional interactions between HIV‐1 integrase (IN) and its cellular cofactors. At present …
New insights into HBV replication: new opportunities for improved therapies
M Nassal - Future Virology, 2009 - Taylor & Francis
HBV is one of the smallest animal viruses yet one of the most successful human pathogens,
inflicting potentially life-threatening liver disease on more than 5% of the global population …
inflicting potentially life-threatening liver disease on more than 5% of the global population …
[HTML][HTML] Structure and biochemical characterization of protein acetyltransferase from Sulfolobus solfataricus
MM Brent, A Iwata, J Carten, K Zhao… - Journal of Biological …, 2009 - ASBMB
The Sulfolobus solfataricus protein acetyltransferase (PAT) acetylates ALBA, an abundant
nonspecific DNA-binding protein, on Lys 16 to reduce its DNA affinity, and the Sir2 …
nonspecific DNA-binding protein, on Lys 16 to reduce its DNA affinity, and the Sir2 …