Metastasis remains the overwhelming cause of death for cancer patients. During metastasis,
cancer cells will leave the primary tumor, intravasate into the bloodstream, arrest at a distant …

Metastasis has intrigued researchers for more than 100 years. Despite the development of
technologies and therapeutic strategies, metastasis is still the major cause of cancer-related …

The so‐called “seed and soil” hypothesis proposed by S tephen P aget in 1889 to explain
the metastatic behavior of cancer cells and the homing of certain cancers to “selected” sites …

The outcome of cancer metastasis depends on multiple interactions (cross-talk) between
selected metastatic cells and homeostatic mechanisms unique to some organ …

The'seed and soil'hypothesis for metastasis sets forth the concept that a conducive
microenvironment, or niche, is required for disseminating tumour cells to engraft distant …

The metastatic spread of tumor cells to distant sites represents the major cause of cancer-
related deaths. Cancer metastasis involves a series of complex interactions between tumor …

Researchers have been studying metastasis for more than 100 years, and only recently
have we gained insight into the mechanisms by which metastatic cells arise from primary …

Metastasis is the consequence of a cancer cell that disperses from the primary tumor, travels
throughout the body, and invades and colonizes a distant site. On the basis of Paget's 1889 …

The concept that the pattern of metastatic spread of cancer is not random and that cancer
cells exhibit preferences when metastasizing to organs, dates back to 1889 when Steven …

Metastasis is a multistage process that requires cancer cells to escape from the primary
tumour, survive in the circulation, seed at distant sites and grow. Each of these processes …