The genetically amenable organism Drosophila melanogaster has been estimated to have
14,076 protein coding genes in the genome, according to the flybase release note R5. 13 …

Regeneration is a complex process that requires a coordinated genetic response to tissue
loss. Signals from dying cells are crucial to this process and are best understood in the …

RNA interference (RNAi) is a powerful and widely used approach to investigate gene
function, but a major limitation of the approach is the high incidence of non-specific …

Abstract The Decapentaplegic (Dpp) and Wingless (Wg) signal pathways play important
roles in numerous biological processes in Drosophila. The Drosophila vestigial (vg) gene is …

Forward genetic screens in model organisms have provided important insights into
numerous aspects of development, physiology and pathology. With the availability of …

Cultured Drosophila cell lines have become an increasingly popular model system for cell
biological and functional genomic studies. One of the most commonly used lines, S2 cells, is …

Apoptosis is one of the main fundamental biological processes required for development of
multicellular organisms. Inappropriate regulation of apoptosis can lead to severe …

Cell death plays a pivotal role in animal development and tissue homeostasis.
Dysregulation of this process is associated with a wide variety of human diseases, including …

Despite the identification of numerous key players of the cell death machinery, little is known
about their physiological role. Using RNA interference (RNAi) in vivo, we have studied the …

Spatio-temporal regulation of the cell death machinery is essential for normal development
and homeostasis of multicellular organisms. While the molecular basis for the central cell …