Age of onset in concordant twins and other relative pairs with multiple sclerosis
AD Sadovnick, IM Yee, C Guimond… - American journal of …, 2009 - academic.oup.com
The ages of onset in multiple sclerosis cases span more than 7 decades. Data are
presented for affected relative pairs from a Canadian population base of 30,000 multiple …
presented for affected relative pairs from a Canadian population base of 30,000 multiple …
Sibship characteristics and risk of multiple sclerosis: A nationwide cohort study in Denmark
P Bager, NM Nielsen, K Bihrmann… - American journal of …, 2006 - academic.oup.com
It has been hypothesized that age at infection with a common microbial agent may be
associated with the risk of multiple sclerosis (MS). The authors addressed this hypothesis by …
associated with the risk of multiple sclerosis (MS). The authors addressed this hypothesis by …
Age of onset in siblings concordant for multiple sclerosis
DE Bulman, AD Sadovnick, GC Ebers - Brain, 1991 - academic.oup.com
We have evaluated genetic and environmental influences in multiple sclerosis (MS) by
comparing age of onset in 99 sibling pairs concordant for the disease. We used three …
comparing age of onset in 99 sibling pairs concordant for the disease. We used three …
Parent-of-origin effect in multiple sclerosis: observations in half-siblings
Multiple sclerosis is a complex trait in which occurrence rates in offspring are 20–50-fold
greater than in the general population. Parent-of-origin effects have been difficult to screen …
greater than in the general population. Parent-of-origin effects have been difficult to screen …
Familial risk of multiple sclerosis: a nationwide cohort study
NM Nielsen, T Westergaard, K Rostgaard… - American journal of …, 2005 - academic.oup.com
Multiple sclerosis (MS) is known to accumulate within families. The magnitude of the familial
risk, however, remains uncertain. Using a nationwide MS register and other national …
risk, however, remains uncertain. Using a nationwide MS register and other national …
Multiple sclerosis and birth order: a longitudinal cohort study
AD Sadovnick, IML Yee, GC Ebers - The Lancet Neurology, 2005 - thelancet.com
Background Genetic epidemiological studies suggest both genetic and environmental
factors have a role in multiple sclerosis (MS). Environmental effects are strongly suggested …
factors have a role in multiple sclerosis (MS). Environmental effects are strongly suggested …
Possible risk factors in multiple sclerosis as found in a national twin study
RD Currier, R Eldridge - Archives of Neurology, 1982 - jamanetwork.com
• Fifty-one twin pairs, one or both members of each with multiple sclerosis (MS), were
analyzed for extraneous events occurring prior to onset. Six patient groupings allowed …
analyzed for extraneous events occurring prior to onset. Six patient groupings allowed …
The epidemiology of multiple sclerosis
W Pryse-Phillips, F Costello - Handbook of multiple sclerosis, 2001 - taylorfrancis.com
I. INTRODUCTION Although there is agreement that exogenous factors are very relevant in
the pathogenesis of multiple sclerosis (MS), the genetic aspects have been studied more …
the pathogenesis of multiple sclerosis (MS), the genetic aspects have been studied more …
No effect of parental age on risk of multiple sclerosis: a population-based study
SV Ramagopalan, DA Dyment, C Guimond, IM Yee… - …, 2010 - karger.com
Background: Genetic and environmental factors have important roles in multiple sclerosis
(MS) susceptibility. A clear parent-of-origin effect has been shown in several populations …
(MS) susceptibility. A clear parent-of-origin effect has been shown in several populations …
Multiple sclerosis recurrence risk for siblings in an isolated population of Central Sardinia, Italy
C Montomoli, I Prokopenko, A Caria… - … Official Publication of …, 2002 - Wiley Online Library
Studies of twins, adoptees, half siblings, and familial recurrence risk have shown that
genetic and non‐genetic factors are involved in multiple sclerosis (MS) etiology. Age at …
genetic and non‐genetic factors are involved in multiple sclerosis (MS) etiology. Age at …