The ages of onset in multiple sclerosis cases span more than 7 decades. Data are
presented for affected relative pairs from a Canadian population base of 30,000 multiple …

It has been hypothesized that age at infection with a common microbial agent may be
associated with the risk of multiple sclerosis (MS). The authors addressed this hypothesis by …

We have evaluated genetic and environmental influences in multiple sclerosis (MS) by
comparing age of onset in 99 sibling pairs concordant for the disease. We used three …

Multiple sclerosis is a complex trait in which occurrence rates in offspring are 20–50-fold
greater than in the general population. Parent-of-origin effects have been difficult to screen …

Multiple sclerosis (MS) is known to accumulate within families. The magnitude of the familial
risk, however, remains uncertain. Using a nationwide MS register and other national …

Background Genetic epidemiological studies suggest both genetic and environmental
factors have a role in multiple sclerosis (MS). Environmental effects are strongly suggested …

• Fifty-one twin pairs, one or both members of each with multiple sclerosis (MS), were
analyzed for extraneous events occurring prior to onset. Six patient groupings allowed …

I. INTRODUCTION Although there is agreement that exogenous factors are very relevant in
the pathogenesis of multiple sclerosis (MS), the genetic aspects have been studied more …

Background: Genetic and environmental factors have important roles in multiple sclerosis
(MS) susceptibility. A clear parent-of-origin effect has been shown in several populations …

Studies of twins, adoptees, half siblings, and familial recurrence risk have shown that
genetic and non‐genetic factors are involved in multiple sclerosis (MS) etiology. Age at …