The Role of the Androgen Receptor Polyglutamine Tract in Prostate Cancer: In Mice and Men
DM Robins - Androgen Action in Prostate Cancer, 2009 - Springer
The androgen receptor (AR) is critical in the initiation and progression of prostate cancer,
and therefore may contribute to disease through its genetic variation. Particular scrutiny has …
and therefore may contribute to disease through its genetic variation. Particular scrutiny has …
Glutamine tract length of human androgen receptors affects hormone-dependent and-independent prostate cancer in mice
MA Albertelli, OA O'Mahony, M Brogley… - Human molecular …, 2008 - academic.oup.com
The androgen receptor (AR) is involved in the initiation and progression of prostate cancer
and its transition to androgen independence. Genetic variation in AR may contribute to …
and its transition to androgen independence. Genetic variation in AR may contribute to …
Structural and functional consequences of glutamine tract variation in the androgen receptor
G Buchanan, M Yang, A Cheong… - Human molecular …, 2004 - academic.oup.com
The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat region,(CAG)
n, in its N-terminal transactivation domain (NTD) that encodes a polyglutamine (polyQ) tract …
n, in its N-terminal transactivation domain (NTD) that encodes a polyglutamine (polyQ) tract …
Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice
MA Albertelli, A Scheller, M Brogley… - Molecular …, 2006 - academic.oup.com
Polymorphism in the length of the N-terminal glutamine (Q) tract in the human androgen
receptor (AR) has been implicated in affecting aspects of male health ranging from fertility to …
receptor (AR) has been implicated in affecting aspects of male health ranging from fertility to …
Genetic variation in the androgen receptor impacts prostate cancer initiation and progression in the humanized AR mouse.
MA Albertelli - 2007 - deepblue.lib.umich.edu
Genetic variation of the androgen receptor (AR) impacts its function in male development
and disease. The length of a polymorphic N-terminal glutamine (Q) tract (CAG repeat) …
and disease. The length of a polymorphic N-terminal glutamine (Q) tract (CAG repeat) …
Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells
Q Wang, TS Udayakumar, TS Vasaitis… - Journal of Biological …, 2004 - ASBMB
Androgen receptor (AR) signaling pathways mediate critical events in normal and neoplastic
prostate growth. Shortening of the polymorphic N-terminal polyglutamine (poly (Q)) tract of …
prostate growth. Shortening of the polymorphic N-terminal polyglutamine (poly (Q)) tract of …
In situ shortening of CAG repeat length within the androgen receptor gene in prostatic cancer and its possible precursors
Y Tsujimoto, T Takakuwa, H Takayama… - The …, 2004 - Wiley Online Library
BACKGROUND The amino‐terminal transcriptional activation domain of the androgen
receptor (AR) gene contains two polymorphic trinucleotide repeat segments that encode …
receptor (AR) gene contains two polymorphic trinucleotide repeat segments that encode …
Androgen receptor variants and prostate cancer in humanized AR mice
DM Robins, MA Albertelli, OA O'Mahony - The Journal of steroid …, 2008 - Elsevier
Androgen, acting via the androgen receptor (AR), is central to male development,
differentiation and hormone-dependent diseases such as prostate cancer. AR is actively …
differentiation and hormone-dependent diseases such as prostate cancer. AR is actively …
Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy
Androgens are involved in the development of several tissues, including prostate, skeletal
muscle, bone marrow, hair follicles, and brain. Most of the biological effects of the androgens …
muscle, bone marrow, hair follicles, and brain. Most of the biological effects of the androgens …
Significance of the polyglutamine tract polymorphism in the androgen receptor
The androgen receptor gene (AR) contains a polymorphic CAG repeat region encoding a
series of glutamines. Since the discovery in 1991 that an expansion of this (CAG) n tract …
series of glutamines. Since the discovery in 1991 that an expansion of this (CAG) n tract …