Chemopreventive efficacy of naproxen and nitric oxide–naproxen in rodent models of colon, urinary bladder, and mammary cancers

VE Steele, CV Rao, Y Zhang, J Patlolla, D Boring… - Cancer Prevention …, 2009 - AACR
Nonsteroidal anti-inflammatory drugs (NSAID) have been highly effective in preventing
colon, urinary bladder, and skin cancer preclinically, and also in clinical trials of colon …

Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model

HL Nicastro, CJ Grubbs, M Margaret Juliana… - Cancer Prevention …, 2014 - AACR
Urinary bladder cancer prevention studies were performed with the nonsteroidal anti-
inflammatory drugs (NSAID) naproxen (a standard NSAID with a good cardiovascular …

The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention

FM Giardiello, GJA Offerhaus, RN DuBois - European Journal of Cancer, 1995 - Elsevier
Colorectal cancer is the second leading cause of cancer death in the USA Recent research
suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the prevention …

Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets

CV Rao, BS Reddy, VE Steele, CX Wang, X Liu… - Molecular cancer …, 2006 - AACR
Nitric oxide–releasing nonsteroidal anti-inflammatory drugs (NO-NSAID) are promising
chemoprevention agents; unlike conventional NSAIDs, they seem free of appreciable …

Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs …

JL Williams, S Borgo, I Hasan, E Castillo, F Traganos… - Cancer Research, 2001 - AACR
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs), consisting of a
known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group …

Colon cancer prevention with NO-releasing NSAIDs

CS Kaza, K Kashfi, B Rigas - Prostaglandins & other lipid mediators, 2002 - Elsevier
A seminal advance in the prevention of colon cancer has been the observation that
nonsteroidal antiinflammatory drugs (NSAIDs) reduce the incidence of and mortality from …

The role of NSAIDs in the prevention of colon cancer

Y Rayyan, J Williams, B Rigas - Cancer investigation, 2002 - Taylor & Francis
The treatment of colorectal cancer continues to improve, but it still remains the second
leading cause of cancer-related death in the United States. In 2001, there will be over …

Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer

W Elsheikh, RW Blackler, KL Flannigan, JL Wallace - Nitric Oxide, 2014 - Elsevier
Regular use of nonsteroidal anti-inflammatory drugs is associated with a significantly lower
incidence of several types of cancer, particularly those affecting the gastrointestinal tract …

Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non‐steroidal anti‐inflammatory drug nabumetone

HK Roy, WJ Karolski, A Ratashak - International journal of …, 2001 - Wiley Online Library
Use of non‐steroidal anti‐inflammatory drugs (NSAIDs) for chemoprevention of colon cancer
has been hindered by their potential gastro‐intestinal toxicity. Nabumetone, which is …

Molecular Alterations Associated with Sulindac-Resistant Colon Tumors in ApcMin/+ Mice

EJ Greenspan, FC Nichols, DW Rosenberg - Cancer Prevention Research, 2010 - AACR
Although nonsteroidal anti-inflammatory drugs (NSAID), including sulindac, have been used
extensively as chemopreventive agents for colorectal cancer, results are not consistent …