The early cortical primordium develops from a sheet of neuroepithelium that is flanked by
distinct signaling centers. Of these, the hem and the antihem are positioned as longitudinal …

Early brain development is regulated by the coordinated actions of multiple signaling
centers at key boundaries between compartments. Three telencephalic midline structures …

The formation of a sharp interface of adjacent subdivisions is important for establishing the
precision of tissue organization, and at specific borders it serves to organize key signaling …

Recent studies have shown that the formation of boundaries between the segments–
rhombomeres–of the vertebrate hindbrain depends on bidirectional signalling between …

The development of the central nervous system (CNS) follows a relatively simple
morphological program. The entire CNS derives from the neural plate, a single layer of …

During early development, the hindbrain is sub-divided into rhombomeres that underlie the
organisation of neurons and adjacent craniofacial tissues. A gene regulatory network of …

Embryonic development of the mammalian forebrain is guided by signals from four
patterning centers. The concerted actions of these signals transform the anterior neural plate …

ABSTRACT The vertebrate Central Nervous System (CNS) originates from the embryonic
dorsal ectoderm. Differentiation of the neural epithelium from the ectoderm and the formation …

The dorsal medial region of the developing mammalian telencephalon plays a central role in
the patterning of the adjacent brain regions. This review describes the development of this …

The molecular mechanisms that govern early patterning of anterior neuroectoderm (ANE) for
the prospective brain region in vertebrates are largely unknown. Screening a cDNA library of …