We describe a sensitive metabolite array for genome sequence–independent functional
analysis of metabolic phenotypes and networks, the reactomes, of cell populations and …

The species complexity of microbial communities and challenges in culturing representative
isolates make it difficult to obtain assembled genomes. Here we characterize and compare …

To demonstrate metabolic pathway analysis and multiomic integration, we describe
representative sample sets in the Supplementary Note, including metabolic pathway …

Metabolons, multiprotein complexes consisting of sequential enzymes of a metabolic
pathway, are proposed to be biosynthetic “hotspots” within the cell. However, experimental …

High-throughput metabolomic experiments aim at identifying and ultimately quantifying all
metabolites present in biological systems. The metabolites are interconnected through …

We demonstrate an integrated approach to build, test, and refine a model of a cellular
pathway, in which perturbations to critical pathway components are analyzed using DNA …

In the post-genomics era, high-throughput techniques for monitoring RNA1 and protein2
levels are well on their way to becoming mainstream tools for monitoring global cell …

To understand basic principles of bacterial metabolism organization and regulation, but also
the impact of genome size, we systematically studied one of the smallest bacteria …

Single-cell metabolomics hits its stride | Nature Methods Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

One of the more provocative realizations that have come out of the genome sequencing
projects is that organisms possess a large number of uncharacterized or poorly …