There is a substantial need to develop better influenza virus vaccines that can protect
populations that are not adequately protected by the currently licensed vaccines. While live …

Natural killer T (NKT)-cells activated with the glycolipid ligand α-galactosylceramide (α-
GalCer) stimulate a wide array of immune responses with many promising …

DNA vaccines can induce both humoral and cellular immune responses in animals.
However, DNA vaccines suffer from limited vaccine potency due to low immunogenicity …

α-Galactosylceramide (α-GalCer) is a safe and effective adjuvant for nasal vaccines and
induces protective immune responses against tumors and viral infections. In our previous …

Abstract α-Galactosylceramide (α-GalCer) is a ligand of invariant Vα14+ NKT cells and is
presented by CD1d molecule on APC. NKT cells produce a large amount of Th1 and Th2 …

α-Galactosylceramide (α-GalCer), originally isolated from a marine sponge, was known to
activate natural killer T (NKT) cells through CD1d-mediated Ag presentation and induce Th1 …

In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by
intranasal coadministration of α-galactosylceramide (α-GalCer) can potently enhance …

Efficient induction of antigen‐specific immunity is achieved by delivering multiple doses of
vaccine formulated with appropriate adjuvants that can harness the benefits of innate …

The ongoing epizootic of highly pathogenic avian H5N1 influenza and its direct
transmissibility and high pathogenicity in humans has led to renewed interest in the …

Influenza A virus infection can predispose to potentially devastating secondary bacterial
infections. Invariant natural killer T (iNKT) cells are unconventional, lipid-reactive T …