Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure

FPA Fabbiani, B Dittrich, AJ Florence, T Gelbrich… - …, 2009 - pubs.rsc.org
Two novel sodium salts of the antibiotic ciprofloxacin were crystallised at pressures of 0.25
and 0.6 GPa and subsequently recovered to ambient pressure. The structures are the first …

Salt screening and characterization of ciprofloxacin

G Zhang, L Zhang, D Yang, N Zhang, L He… - … Section B: Structural …, 2016 - scripts.iucr.org
With the aim of improving the solubility of ciprofloxacin, polybasic organic acids were utilized
to react with ciprofloxacin in different stoichiometric proportions. The use of the solvent drop …

Structural origin of physicochemical properties differences upon dehydration and polymorphic transformation of ciprofloxacin hydrochloride revealed by structure …

OD Putra, A Pettersen, E Yonemochi, H Uekusa - CrystEngComm, 2020 - pubs.rsc.org
Ciprofloxacin hydrochloride (CIP) is a common fluoroquinolone antibiotic agent, and in the
marketed product the compound exists as the hydrate phase (1.43 hydrate). Upon heating …

Ciprofloxacin salts with benzoic acid derivatives: structural aspects, solid-state properties and solubility performance

AO Surov, NA Vasilev, AP Voronin, AV Churakov… - …, 2020 - pubs.rsc.org
In this work, three new pharmaceutical hydrated salts of ciprofloxacin with selected
derivatives of benzoic acid, namely 4-hydroxybenzoic acid, 4-aminobenzoic acid and gallic …

Solid forms of ciprofloxacin salicylate: polymorphism, formation pathways, and thermodynamic stability

AO Surov, NA Vasilev, AV Churakov, J Stroh… - Crystal Growth & …, 2019 - ACS Publications
The crystallization of ciprofloxacin—an antibacterial fluoroquinolone compound—with
salicylic acid resulted in the isolation of five distinct solid forms of the drug, namely, an …

Two faces of ciprofloxacin: investigation of proton transfer in solid state transformations

H Mesallati, NA Mugheirbi, L Tajber - Crystal Growth & Design, 2016 - ACS Publications
Ciprofloxacin (CIP) can exist in two different forms: the zwitterion and the un-ionized form.
While the crystal structure of each has been described independently, the ability of CIP to …

A device to crystallize organic solids: structure of ciprofloxacin, midazolam, and ofloxacin as targets

S Mahapatra, KN Venugopala… - Crystal growth & …, 2010 - ACS Publications
The crystal structure determination of the anhydrous form of any organic compound has
been a challenge because of solvent incorporation during crystallization. A device to grow …

Ciprofloxacin hippurate salt: crystallization tactics, structural aspects, and biopharmaceutical performance

R Chadha, P Singh, S Khullar… - Crystal Growth & …, 2016 - ACS Publications
Ciprofloxacin is a widely prescribed fluoroquinolone antibacterial for the treatment of several
types of bacterial infections; however, it suffers from unfavorable biopharmaceutical …

Revisiting the solid state of norfloxacin

C Puigjaner, R Barbas, A Portell… - Crystal growth & …, 2010 - ACS Publications
The crystal polymorphism of Norfloxacin and its hydrates has been revisited in order to
update the knowledge about the solid state behavior of this active pharmaceutical …

Crystal structure of levofloxacin anhydrates: a high-temperature powder X-ray diffraction study versus crystal structure prediction

JTJ Freitas, CC de Melo, OMMS Viana… - Crystal Growth & …, 2018 - ACS Publications
Levofloxacin, the levo-isomer of the antibiotic ofloxacin, can crystallize into two different
hydrate forms, the monohydrate and the hemihydrate. Although these forms are well …