Elaborate DNA repair mechanisms have evolved, allowing cells to repair damages in their
genomes. Nucleotide excision repair (NER) removes a variety of helix-distorting lesions …

Upon DNA damage, eukaryotic cells activate a conserved signal transduction cascade
known as the DNA damage checkpoint (DDC). We investigated the influence of DDC …

To safeguard the genome from the accumulation of deleterious effects arising from DNA
lesions, cells developed several DNA repair mechanisms that remove specific types of …

The mechanisms used by checkpoints to identify DNA lesions are poorly understood and
may involve the function of repair proteins. Looking for mutants specifically defective in …

The stability and integrity of the genome is crucial for all cellular life on earth. This integrity is
continuously challenged by internal and external genotoxic agents. These agents cause …

The DNA damage checkpoint is a surveillance mechanism activated by DNA lesions and
devoted to the maintenance of genome stability. It is considered as a signal transduction …

A cell's genome is under constant threat of damage, which if not repaired can lead to
mutations or cell death. Common forms of DNA damage found in nature include cyclobutane …

Genomic integrity is threatened by DNA damage that, if not properly repaired, can be
converted into mutations, whose accumulation leads to genomic instability, one of the …

A network of DNA damage surveillance systems is triggered by sensing of DNA lesions and
the initiation of a signal transduction cascade that activates genome-protection pathways …

Eukaryotic cells respond to a variety of DNA insults by triggering a common signal
transduction cascade, known as checkpoint response, which temporarily halts cell-cycle …