There is a growing body of evidence suggesting that alterations in the adhesion properties
of neoplastic cells endow them with an invasive and migratory phenotype. Indeed, changes …

In addition to mediating cell adhesion, many cell adhesion molecules act as tumor
suppressors. These proteins are capable of restricting cell growth mainly through contact …

Abstract Changes in cell–cell and cell–matrix adhesion accompany the transition from
benign tumours to invasive, malignant cancer and the subsequent metastatic dissemination …

Multiple and diverse cell adhesion molecules take part in intercellular and cell-extracellular
matrix interactions of cancer. Cancer progression is a multi-step process in which some …

Cell adhesion is a key process, elementary in the establishment of tissue architecture and
differentiation. In neoplasia, in which there is a disruption of tissue architecture and a …

Adhesive properties of tumor cells have long been considered important for metastasis
formation [1]. Reduced mutual or'homotypic'adhesion between cancer cells has been …

It is now clear that adhesive interactions play a critical role in the process of metastatic tumor
dissemination. Adhesion molecules act as both positive and negative modulators of the …

The past decade has witnessed substantial progress in our understanding of the molecular
mechanisms of tumor cell interactions with vascular endothelium and extracellular matrix …

Tumor cells often show a decrease in cell–cell and/or cell–matrix adhesion. An increasing
body of evidence indicates that this reduction in cell adhesion correlates with tumor invasion …

Cancer metastasis poses the greatest challenge to the eradication of malignancy. The
majority of clinical and experimental evidence indicates that metastasis is a non-random …