Fibrillization or conformational change of α-synuclein is central in the pathogenesis of α-
synucleinopathies, such as Parkinson disease. We found that the A30P mutant accelerates …

α-Synuclein (AS) is associated with both sporadic and familial forms of Parkinson disease
(PD). In sporadic disease, wild-type AS fibrillates and accumulates as Lewy bodies within …

The generation of α-synuclein (α-syn) truncations from incomplete proteolysis plays a
significant role in the pathogenesis of Parkinson's disease. It is well established that C …

Substantial evidence suggests that the fibrillation of α-synuclein is a critical step in the
development of Parkinson's disease. In vitro, α-synuclein forms fibrils with morphologies and …

The Parkinson's disease (PD) substantia nigra is characterized by the presence of Lewy
bodies containing fibrillar α-synuclein. Early-onset PD has been linked to two point …

Parkinson's disease involves the loss of dopaminergic neurons in the substantia nigra,
leading to movement disorders. The pathological hallmark of Parkinson's disease is the …

α-Synuclein is a neural protein that comprises the fibrillar core of Lewy bodies, a
histologically defining lesion of Parkinson's disease. To investigate the role of each specific …

Lewy bodies, hallmarks of Parkinson's disease, contain C-terminally truncated (ΔC) α-
synuclein (α-syn). Here, we report fibril structures of three N-terminally acetylated (Ac) α-syn …

Elucidating the details of the assembly of amyloid fibrils is a key step to understanding the
mechanism of amyloid deposition diseases including Parkinson's disease. Although several …

The aggregation and fibrillation of α-synuclein has been implicated as a causative factor in
the Parkinson's disease. The hexamer motif KTKEGV is found in each of the seven imperfect …