Most experimental work addressing cyclooxygenase‐2 (COX‐2) inhibitor has focused on
suppressing hematogenic spread. Little is known about the mechanism by which this …

The mechanisms underlying the effects of COX‐2 on tumor lymphangiogenesis remain
largely undefined. Here, the human lung cancer cell lines A549, 95D, Anip973, and AGZY83 …

Abstract Cyclooxygenase-2 (COX-2) inhibitor has been reported to suppress tumor
progression. However, it is unclear whether this inhibitor can also prevent lymphatic …

The objective of the present study was to investigate whether cyclooxygenase-2 (COX-2) is
associated with malignancy, and to investigate its molecular mechanisms in human lung …

Lymphangiogenesis has been shown to promote lymph node metastasis in cancers, making
it an important target in cancer therapy. Vascular endothelial growth factor (VEGF)-C is …

Abstract Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin H synthase, has
been implicated in the progression of human lung adenocarcinoma. However, the …

BACKGROUND AND AIMS: Recent observations suggest an implication of cyclooxygenase-
2 (COX-2) in tumor lymphangiogenesis through an upregulation of vascular endothelial …

Background Lymphangiogenesis has become a new research frontier in tumor metastasis
since the discovery of reliable lymphatic markers that have allowed observation and …

Abstract Background Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG)
synthase, has been implicated in tumor metastasis. Interaction of COX-2 with its specific EP …

Previous studies have suggested that cyclooxygenase-2 (COX-2) over-expression is
associated with angiogenesis in gastric cancer. However, the relationship between COX-2 …