Among all of the genetic factors associated with multiple sclerosis (MS) susceptibility, MHC
class II molecules have the strongest association. Although a direct role of DR alleles in MS …

The human MHC class II genes are associated with genetic susceptibility to multiple
sclerosis (MS), a chronic inflammatory demyelinating disease of the CNS of presumed …

Multiple sclerosis (MS), an inflammatory and demyelinating autoimmune disease of CNS
has both, a genetic and an environmental predisposition. Among all the genetic factors …

Multiple sclerosis is an inflammatory, demyelinating disease of the CNS of presumed
autoimmune origin. Of all the genetic factors linked with multiple sclerosis, MHC class II …

To investigate the contribution of human leukocyte antigen (HLA) class II molecules in
susceptibility to inflammatory demyelination, we induced experimental autoimmune …

Previously we showed that transgenic mice expressing human HLA-DR3 gene are
susceptible to PLP91–110 induced experimental autoimmune encephalomyelitis (EAE) and …

Transgenic mice expressing human HLA class II molecules provide a useful model for
identifying HLA-restricted CD4+ epitopes. However, the influence of endogenous murine H …

Background Multiple sclerosis (MS) is associated with pathogenic autoimmunity primarily
focused on major CNS-myelin target antigens including myelin basic protein (MBP) …

Genetic susceptibility to multiple sclerosis (MS) has been linked to the HLA-DR15 haplotype
consisting of DRB1* 15: 01 (DR2b) and DRB5* 01: 01 (DR2a) alleles. Given almost …

Multiple sclerosis (MS) is strongly associated with the HLA‐Dw2 haplotype DRw15. DQw6 in
Caucasoids, although the relative contributions of DR and DQ loci to disease susceptibility …