The MHC class II association with MS is not as straightforward as previously thought. A
complete understanding of the epistatic interactions and epigenetic features of this region …

Multiple sclerosis (MS) susceptibility is characterized by maternal parent-of-origin effects
and increased female penetrance. In 7796 individuals from 1797 MS families (affected …

The major histocompatibility complex (MHC) region is strongly associated with multiple
sclerosis (MS) susceptibility. HLA-DRB1* 15: 01 has the strongest effect, and several other …

Susceptibility to multiple sclerosis (MS) is associated with genes encoding the class II
proteins of the major histocompatibility complex (MHC) and the T cell receptor (TcR) o …

Histocompatibility Determinants in Multiple Sclerosis Page 1 Transplant. Rev. (1975), Vol. 22
Published by Munksgaard, Copenhagen, Denmark No part may be reproduced by any process …

The disease mechanism of multiple sclerosis (MS) involves inflammation, demyelination and
neurodegeneration. The relation between these components is not completely understood …

Multiple sclerosis is considered to be an immune‐mediated disease of the central nervous
system, characterized by chronic inflammation, primary demyelination and axonal damage …

A large body of immunologic, epidemiologic, and genetic data indicate that tissue inury in
multiple sclerosis (MS) results from an abnormal immune response to one or more myelin …

Objective To determine the relationship between highly-conserved extended-haplotypes
(CEHs) in the major histocompatibility complex (MHC) and MS-susceptibility. Background …

Demyelination in multiple sclerosis and in animal models is associated with infiltrating CD8+
and CD4+ T cells. Although oligodendrocytes and axons are damaged in these diseases …