Multiple sclerosis and the major histocompatibility complex
SV Ramagopalan, JC Knight… - Current opinion in …, 2009 - journals.lww.com
The MHC class II association with MS is not as straightforward as previously thought. A
complete understanding of the epistatic interactions and epigenetic features of this region …
complete understanding of the epistatic interactions and epigenetic features of this region …
Parent-of-origin effects at the major histocompatibility complex in multiple sclerosis
MJ Chao, BM Herrera, SV Ramagopalan… - Human molecular …, 2010 - academic.oup.com
Multiple sclerosis (MS) susceptibility is characterized by maternal parent-of-origin effects
and increased female penetrance. In 7796 individuals from 1797 MS families (affected …
and increased female penetrance. In 7796 individuals from 1797 MS families (affected …
Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects
NA Patsopoulos, LF Barcellos, RQ Hintzen… - PLoS …, 2013 - journals.plos.org
The major histocompatibility complex (MHC) region is strongly associated with multiple
sclerosis (MS) susceptibility. HLA-DRB1* 15: 01 has the strongest effect, and several other …
sclerosis (MS) susceptibility. HLA-DRB1* 15: 01 has the strongest effect, and several other …
Multiple sclerosis and its animal models: the role of the major histocompatibility complex and the T cell receptor repertoire
L Steinman - Springer seminars in immunopathology, 1992 - Springer
Susceptibility to multiple sclerosis (MS) is associated with genes encoding the class II
proteins of the major histocompatibility complex (MHC) and the T cell receptor (TcR) o …
proteins of the major histocompatibility complex (MHC) and the T cell receptor (TcR) o …
[引用][C] Histocompatibility determinants in multiple sclerosis
C Jersild, B Dupont, T Fog, PJ Platz… - Immunological …, 1975 - Wiley Online Library
Histocompatibility Determinants in Multiple Sclerosis Page 1 Transplant. Rev. (1975), Vol. 22
Published by Munksgaard, Copenhagen, Denmark No part may be reproduced by any process …
Published by Munksgaard, Copenhagen, Denmark No part may be reproduced by any process …
The immunology of multiple sclerosis: disease mechanisms and therapeutic targets.
T Holmøy - Minerva medica, 2008 - europepmc.org
The disease mechanism of multiple sclerosis (MS) involves inflammation, demyelination and
neurodegeneration. The relation between these components is not completely understood …
neurodegeneration. The relation between these components is not completely understood …
Expression of major histocompatibility complex class l molecules on the different cell types in multiple sclerosis lesions
R Höftberger, F Aboul‐Enein, W Brueck… - Brain …, 2004 - Wiley Online Library
Multiple sclerosis is considered to be an immune‐mediated disease of the central nervous
system, characterized by chronic inflammation, primary demyelination and axonal damage …
system, characterized by chronic inflammation, primary demyelination and axonal damage …
Multiple sclerosis: genomic rewards
JR Oksenberg, SE Baranzini, LF Barcellos… - Journal of …, 2001 - Elsevier
A large body of immunologic, epidemiologic, and genetic data indicate that tissue inury in
multiple sclerosis (MS) results from an abnormal immune response to one or more myelin …
multiple sclerosis (MS) results from an abnormal immune response to one or more myelin …
Highly conserved extended haplotypes of the major histocompatibility complex and their relationship to multiple sclerosis susceptibility
Objective To determine the relationship between highly-conserved extended-haplotypes
(CEHs) in the major histocompatibility complex (MHC) and MS-susceptibility. Background …
(CEHs) in the major histocompatibility complex (MHC) and MS-susceptibility. Background …
In vivo expression of major histocompatibility complex molecules on oligodendrocytes and neurons during viral infection
JM Redwine, MJ Buchmeier, CF Evans - The American journal of pathology, 2001 - Elsevier
Demyelination in multiple sclerosis and in animal models is associated with infiltrating CD8+
and CD4+ T cells. Although oligodendrocytes and axons are damaged in these diseases …
and CD4+ T cells. Although oligodendrocytes and axons are damaged in these diseases …