Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy

M Nazıroğlu - Neurochemical research, 2009 - Springer
Epilepsy is one of the oldest neurological conditions known to humankind. It is known that
oxidative stress and generation of reactive oxygen species are a cause and consequence of …

Selenium and intractable epilepsy: is there any correlation?

MR Ashrafi, R Shabanian, A Abbaskhanian… - Pediatric …, 2007 - Elsevier
Oxidative stress and generation of reactive oxygen species are strongly implicated in a
number of neuronal and neuromuscular disorders, including epilepsy. The functions of …

A probable causative factor for an old problem: selenium and glutathione peroxidase appear to play important roles in epilepsy pathogenesis

MR Ashrafi, S Shams, M Nouri, M Mohseni… - …, 2007 - Wiley Online Library
Purpose: Only recently has it become known that oxidative stress and generation of reactive
oxygen species are the cause and the consequence of epileptic seizures. Due to the …

Selenium and selenoprotein function in brain disorders

R Pillai, JH Uyehara‐Lock, FP Bellinger - IUBMB life, 2014 - Wiley Online Library
Selenoproteins are important for normal brain function, and decreased function of
selenoproteins can lead to impaired cognitive function and neurological disorders. This …

Deficiency of selenium and zinc as a causative factor for idiopathic intractable epilepsy

M Seven, SY Basaran, M Cengiz, S Unal, A Yuksel - Epilepsy research, 2013 - Elsevier
PURPOSE: The accumulation of free radicals may lead to seizures and increase the risk of
their recurrence. Glutathione peroxidase and superoxide dismutase are 2 major enzymes …

Effects of antiepileptic drugs on antioxidant and oxidant molecular pathways: focus on trace elements

M Nazıroğlu, VA Yürekli - Cellular and molecular neurobiology, 2013 - Springer
Current reports on trace elements, oxidative stress, and the effect of antiepileptic drugs are
poor and controversial. We aimed to review effects of most common used antiepileptics on …

Selenium and brain function: a poorly recognized liaison

U Schweizer, AU Bräuer, J Köhrle, R Nitsch… - Brain Research …, 2004 - Elsevier
Molecular biology has recently contributed significantly to the recognition of selenium (Se) 2
and Se-dependent enzymes as modulators of brain function. Increased oxidative stress has …

Selenium in the therapy of neurological diseases. Where is it going?

A Dominiak, A Wilkaniec… - Current …, 2016 - ingentaconnect.com
Selenium (34Se), an antioxidant trace element, is an important regulator of brain function.
These beneficial properties that Se possesses are attributed to its ability to be incorporated …

[HTML][HTML] The neurobiology of selenium: Looking back and to the future

U Schweizer, S Bohleber, W Zhao… - Frontiers in …, 2021 - frontiersin.org
Eighteen years ago, unexpected epileptic seizures in Selenop-knockout mice pointed to a
potentially novel, possibly underestimated, and previously difficult to study role of selenium …

Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling

ND Solovyev - Journal of inorganic biochemistry, 2015 - Elsevier
Multiple biological functions of selenium manifest themselves mainly via 25 selenoproteins
that have selenocysteine at their active centre. Selenium is vital for the brain and seems to …