A novel cyclin, CCNY, was identified as a PFTK1 interacting protein in a yeast two-hybrid
screen. The cyclin box in CCNY and the PFTAIRE motif in PFTK1 are both required for the …

Cyclin-dependent kinases (CDKs) are crucial regulators of the eukaryotic cell cycle whose
activities are controlled by associated cyclins. PFTK1 shares limited homology to CDKs, but …

PCTAIRE-1 (cyclin-dependent kinase [CDK] 16) is a highly conserved serine/threonine
kinase that belongs to the CDK family of protein kinases. Little is known regarding PCTAIRE …

FK 506, a powerful immunosuppressant that blocks allograft rejection by preventing T-cell
activation, binds to an 11-kDa protein called the FK 506-binding protein (FKBP). Like …

PCTAIRE-1 is a member of the cyclin-dependent kinase (cdk) family whose function is
unknown. We examined the pattern of PCTAIRE-1 protein expression in a number of normal …

We isolated a novel member of putative Cdc2-related serine/threonine protein kinases from
a Hela cell cDNA library. The cDNA encodes a protein of 469 amino acids, sharing 95 …

Figure 1. Comparison between Skp2 and FoXo1 for their cytoplasmic localization by a
constitutively active Akt1. 293t cells were transfected with flag-tagged wild type Skp2 or the∆ …

Two different inhibitory domains, N-terminus and central domain, keep FOXM1c almost
inactive despite its strong transactivation domain. Here, we demonstrate that cyclin E/Cdk2 …

We screened the Dictyostelium discoideum two-hybrid cDNA library with the SNW/SKIP
transcription coregulator SnwA and identified a novel cyclophilin CypE. Independently, the …

Cyclin E, an activator of cyclin-dependent kinase 2 (Cdk2), is targeted for proteasomal
degradation by phosphorylation-dependent multiubiquitylation via the ubiquitin ligase SCF …