We have demonstrated that mesenchymal stem cells overexpressing the survival gene Akt
can confer paracrine protection to ischemic myocytes both in vivo and in vitro through the …

Wnt signaling has diverse actions in cardiovascular development and disease processes.
Secreted frizzled-related protein 5 (Sfrp5) has been shown to function as an extracellular …

Secreted frizzled-related protein (Sfrp) 4 is a protein that involve in cardiac development and
several cardiovascular diseases. However, the effect of Sfrp4 in mediating myocardial …

Background—The Wnt/β-catenin signaling pathway plays a central role during cardiac
development and has been implicated in cardiac remodeling and aging. However, the role …

Secreted frizzled-related proteins (Sfrps) are a family of secreted proteins that bind
extracellularly to Wnt ligands and frizzled receptors. This binding modulates the Wnt …

Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases.
Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair …

The Wnt signaling pathway plays important roles in organ development and disease
processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling …

Objective: Overload-induced heart failure is associated with myocyte apoptosis induced by
unknown mechanisms. Wnt genes encode secreted signaling molecules that bind to frizzled …

Expression of the Wnt modulator secreted frizzled related protein 4 (Sfrp4) is upregulated
after heart ischemic injury. We show that intramuscular administration of recombinant Sfrp4 …

Secreted Frizzled-related protein 2 (sFRP2) plays a key role in chronic fibrosis after
myocardial infarction and in heart failure. The aim of this study was to elucidate the …